Evidence map›Paper›PMID 20350943›Full record

ArticleAntimicrobial agents and chemotherapy2010

Emergence of ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates from healthy children and pediatric patients in Portugal.

Renato Pires, Carmen Ardanuy, Dora Rolo, Ana Morais, António Brito-Avô, José Gonçalo-Marques, Josefina Liñares, Ilda Santos-Sanches

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Molecular Cloning and Docking ofFrontiers in microbiology · 2018
    Article
  4. Article
  5. Article
  6. Characterization of levofloxacin non-susceptible clinical Streptococcus pyogenes isolated in the central part of Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Global fluoroquinolone resistance epidemiology and implictions for clinical use.Interdisciplinary perspectives on infectious diseases · 2012
    Article
  12. Epidemiological and molecular analysis of Streptococcus pyogenes isolates causing invasive disease in Spain (1998-2009): comparison with non-invasive isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Renato PiresCentro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, Caparica, Portugal.
Carmen Ardanuy
Dora Rolo
Ana Morais
António Brito-Avô
José Gonçalo-Marques
Josefina Liñares
Ilda Santos-Sanches
Bellvitge University Hospital · ESUniversidade Nova de Lisboa · PTCentro de Investigación Biomédica en Red de Enfermedades Respiratorias · ESHospital de Santa Maria · PT

Funding

Wellcome Trust
6 · The paper itself

Abstract

We describe 66 ciprofloxacin-nonsusceptible Streptococcus pyogenes isolates recovered from colonized and infected children. The ParC S79A substitution was frequent and associated with the emm6/sequence type 382 (emm6/ST382) lineage. The ParC D83G substitution was detected in two isolates (emm5/ST99 and emm28/ST52 lineages). One isolate (emm89/ST101) had no quinolone resistance-determining region codon substitutions or other resistance mechanisms. Five of 66 isolates were levofloxacin resistant. Although fluoroquinolones are not used in children, they may be putative disseminators of fluoroquinolone-nonsusceptible strains in the community.

Indexed as

Amino Acid SubstitutionAnti-Bacterial AgentsAntigens, BacterialBacterial Outer Membrane ProteinsBacterial Typing TechniquesCarrier ProteinsChildCiprofloxacinDrug Resistance, BacterialHumansMolecular EpidemiologyNorfloxacinPoint MutationPortugalStreptococcal InfectionsStreptococcus pyogenesAnti-Bacterial AgentsAntigens, BacterialBacterial Outer Membrane ProteinsCarrier ProteinsCiprofloxacinNorfloxacinstreptococcal M protein

Identifiers

PMID20350943
PMCPMC2876401
OpenAlexW2150631608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.