ArticlePharmacogenomics2010
Pharmacogenomics and bioinformatics: PharmGKB.
Article in Pharmacogenomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- Knowledgebase strategies to aid interpretation of clinical correlation research.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Genetic variation of pharmacogenomic VIP variants in the Chinese Li population: an updated research.Molecular genetics and genomics : MGG · 2022Article
- Search and visualization of gene-drug-disease interactions for pharmacogenomics and precision medicine research using GeneDive.Journal of biomedical informatics · 2021Article
- An Automated Functional Annotation Pipeline That Rapidly Prioritizes Clinically Relevant Genes for Autism Spectrum Disorder.International journal of molecular sciences · 2020Article
- Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling.Drug discovery today · 2020Review
- Precision Pharmacotherapy: Integrating Pharmacogenomics into Clinical Pharmacy Practice.Journal of the American College of Clinical Pharmacy : JACCP · 2019Article
- Article
- Annotation and detection of drug effects in text for pharmacovigilance.Journal of cheminformatics · 2018Article
- PharmGKB: A worldwide resource for pharmacogenomic information.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology.Nucleic acids research · 2018Article
- Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells.The pharmacogenomics journal · 2018Article
- Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer.Molecular oncology · 2017Article
- Characterizing Pharmacogenomic-Guided Medication Use With a Clinical Data Repository.Clinical pharmacology and therapeutics · 2017Article
- Impact of germline and somatic missense variations on drug binding sites.The pharmacogenomics journal · 2017Article
- Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols.Methods in molecular biology (Clifton, N.J.) · 2017Article
- The Application of Genomics in Diabetes: Barriers to Discovery and Implementation.Diabetes care · 2016Article
- A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism.PLoS computational biology · 2016Article
- Systems pharmacology to investigate the interaction of berberine and other drugs in treating polycystic ovary syndrome.Scientific reports · 2016Article
- Ontology-based Vaccine and Drug Adverse Event Representation and Theory-guided Systematic Causal Network Analysis toward Integrative Pharmacovigilance Research.Current pharmacology reports · 2016Article
- Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk.Human genetics · 2016Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The NIH initiated the PharmGKB in April 2000. The primary mission was to create a repository of primary data, tools to track associations between genes and drugs, and to catalog the location and frequency of genetic variations known to impact drug response. Over the past 10 years, new technologies have shifted research from candidate gene pharmacogenetics to phenotype-based pharmacogenomics with a consequent explosion of data. PharmGKB has refocused on curating knowledge rather than housing primary genotype and phenotype data, and now, captures more complex relationships between genes, variants, drugs, diseases and pathways. Going forward, the challenges are to provide the tools and knowledge to plan and interpret genome-wide pharmacogenomics studies, predict gene-drug relationships based on shared mechanisms and support data-sharing consortia investigating clinical applications of pharmacogenomics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.