Evidence map›Paper›PMID 20349353›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011

Determinants of quality of life in patients with advanced cancer.

Camilla Zimmermann, Debika Burman, Nadia Swami, Monika K Krzyzanowska, Natasha Leighl, Malcolm Moore, Gary Rodin, Ian Tannock

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Measuring individual quality of life in patients receiving radiation therapy: the SEIQoL-Questionnaire.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014
    Trial
  4. Does gender influence outcomes from a multidisciplinary intervention for quality of life designed for patients with advanced cancer?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Trial
  5. Trial
  6. Trial
  7. Article
  8. Observational
  9. Review
  10. Observational
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Optimism and social support as contributing factors to spirituality in Cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  17. Article
  18. Review
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Camilla ZimmermannDivision of Medical Oncology and Hematology, Department of Medicine, Toronto, Canada. camilla.zimmermann@uhn.on.ca
Debika Burman
Nadia Swami
Monika K Krzyzanowska
Natasha Leighl
Malcolm Moore
Gary Rodin
Ian Tannock
Princess Margaret Cancer Centre · CAUniversity Health Network · CAUniversity of Toronto · CAZimmerman Associates (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeImproving health-related quality of life (HRQL) is the main goal of palliative care and an important outcome for oncology trials. This study examines medical and sociodemographic determinants of HRQL in outpatients with advanced cancer.

methodsPatients with metastatic gastrointestinal, genitourinary, breast, lung or gynecological cancer, ECOG 0-2, and clinical prognosis of 6 months to 2 years were recruited from outpatient medical oncology clinics. HRQL was measured using the FACT-G questionnaire and the FACIT-Sp meaning and peace (existential) subscale. The influence of demographic and medical characteristics on HRQL was determined using t tests and analysis of variance, with Tukey's correction for multiple comparisons. Multivariate linear regression was used to determine independent predictors.

resultsOf 285 patients, 57% were female and the median age was 61 years; 44% were alive at latest follow-up; and of those deceased, the mean survival time was 10 months. The strongest determinants of overall HRQL were increased age (p < 0.001), good performance status (PS; p < 0.001) and survival time >6 months (p = 0.001). Compared to patients receiving cancer treatment, those awaiting new treatment had worse emotional well-being (p < 0.001), while those on surveillance or whose treatment had been stopped had worse existential well-being (p = 0.03). Male gender predicted better emotional and physical well-being and lower income predicted worse social well-being.

conclusionsAge, PS, survival time, and treatment status are important determinants of HRQL in patients with advanced cancer. Decision aids, open communication, and involvement of supportive care specialists may improve emotional and existential distress associated with changing or stopping cancer treatment.

Indexed as

Quality of LifeAge FactorsFemaleFollow-Up StudiesHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm MetastasisNeoplasmsPalliative CarePrognosisSex FactorsSurveys and QuestionnairesSurvival Rate

Identifiers

PMID20349353
OpenAlexW2160696094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.