ArticleMolecular biology reports2011
Microarray analysis of the gene expression profile in the midgut of silkworm infected with cytoplasmic polyhedrosis virus.
Article in Molecular biology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Genome-scale DNA methylome and transcriptome profiling of midgut of Bombyx mori infected with BmCPV.Scientific data · 2026Article
- Changes in gene expression levels caused by H3K9me3/H3K9ac modifications are associated with BmCPV infection inVirulence · 2025Article
- The mechanisms and factors that induce trained immunity in arthropods and mollusks.Frontiers in immunology · 2023Review
- The Intestinal Immune Defense System in Insects.International journal of molecular sciences · 2022Review
- Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection.Frontiers in immunology · 2022Article
- BmCPV-Derived Circular DNA vcDNA-S7 Mediated byFrontiers in immunology · 2022Article
- Transcriptional responses of Daphnis nerii larval midgut to oral infection by Daphnis nerii cypovirus-23.Virology journal · 2021Article
- Host Response against Virus Infection in an Insect: Bidensovirus Infection Effect on Silkworm (Antioxidants (Basel, Switzerland) · 2021Review
- Vegetative Insecticidal Protein (Vip): A Potential Contender FromFrontiers in microbiology · 2021Review
- Transcriptional response of immune-related genes after endogenous expression of VP1 and exogenous exposure to VP1-based VLPs and CPV virions in lepidopteran cell lines.Molecular genetics and genomics : MGG · 2019Article
- Identification and Expression Analysis of Four Small Heat Shock Protein Genes in Cigarette Beetle,Insects · 2019Article
- Molecular and biochemical responses in the midgut of the silkworm, Bombyx mori, infected with Nosema bombycis.Parasites & vectors · 2018Article
- DNA methylation in silkworm genome may provide insights into epigenetic regulation of response to Bombyx mori cypovirus infection.Scientific reports · 2017Article
- Inhibition of miR-274-3p increases BmCPV replication by regulating the expression of BmCPV NS5 gene in Bombyx mori.Virus genes · 2017Article
- Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus Bin toxin.PloS one · 2017Article
- Analysis of gene expression in the midgut of Bombyx mori during the larval molting stage.BMC genomics · 2016Article
- Transcriptome analysis of interactions between silkworm and cytoplasmic polyhedrosis virus.Scientific reports · 2016Article
- Selection of reference genes for analysis of stress-responsive genes after challenge with viruses and temperature changes in the silkworm Bombyx mori.Molecular genetics and genomics : MGG · 2016Article
- Transcriptome Analysis of the Midgut of the Chinese Oak Silkworm Antheraea pernyi Infected with Antheraea pernyi Nucleopolyhedrovirus.PloS one · 2016Article
- Lack of Connection Between Midgut Cell Autophagy Gene Expression and BmCPV Infection in the Midgut of Bombyx mori.Journal of insect science (Online) · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to obtain an overall view on silkworm response to Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection, a microarray system comprising 22,987 oligonucluotide 70-mer probes was employed to compare differentially expressed genes in the midguts of BmCPV-infected and normal silkworm larvae. At 72 h post-inoculation, 258 genes exhibited at least 2.0-fold differences in expression level. Out of these, 135 genes were up-regulated, while 123 genes were down-regulated. According to gene ontology (GO), 140 genes were classified into GO categories. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicates that 35 genes were involved in 10 significant (P<0.05) KEGG pathways. The expressions of genes related to valine, leucine, and isoleucine degradation, retinol metabolism, and vitamin B6 metabolism were all down-regulated. The expressions of genes involved in ribosome and proteasome pathway were all up-regulated. Quantitative real-time polymerase chain reaction was performed to validate the expression patterns of 13 selected genes of interest. The results suggest that BmCPV infection resulted in the disturbance of protein and amino acid metabolism and a series of major physiological and pathological changes in silkworm. Our results provide new insights into the molecular mechanism of BmCPV infection and host cell response.
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