ReviewNeurogenetics2010
RNA processing pathways in amyotrophic lateral sclerosis.
Review in Neurogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed.
- Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis.Brain : a journal of neurology · 2024Review
- Association of serum Spp1 levels with disease progression in ALS and SBMA.Annals of clinical and translational neurology · 2024Article
- TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Tie-Line Analysis Reveals Interactions Driving Heteromolecular Condensate Formation.Physical review. X · 2022Article
- Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.Scientific reports · 2021Article
- Widespread intron retention impairs protein homeostasis in C9orf72 ALS brains.Genome research · 2020Article
- Rare Angiogenin and Ribonuclease 4 variants associated with amyotrophic lateral sclerosis exhibit loss-of-function: a comprehensive in silico study.Metabolic brain disease · 2019Article
- Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.Human molecular genetics · 2018Article
- TDP-43 suppresses tau expression via promoting its mRNA instability.Nucleic acids research · 2017Article
- ALS mutations in TLS/FUS disrupt target gene expression.Genes & development · 2015Article
- Exploring new pathways of neurodegeneration in ALS: the role of mitochondria quality control.Brain research · 2015Review
- Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.Human molecular genetics · 2015Article
- A network of RNA and protein interactions in Fronto Temporal Dementia.Frontiers in molecular neuroscience · 2015Review
- Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene.Molecular neurodegeneration · 2014Article
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Nature chemical biology · 2014Article
- Review
- Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for new therapeutic targets?Neurodegenerative disease management · 2014Article
- Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2013Article
- ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.Human molecular genetics · 2013Article
- Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.Angiogenesis · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA processing is a tightly regulated, highly complex pathway which includes RNA transcription, pre-mRNA splicing, editing, transportation, translation, and degradation of RNA. Over the past few years, several RNA processing genes have been shown to be mutated or genetically associated with amyotrophic lateral sclerosis (ALS), including the RNA-binding proteins TDP-43 and FUS/TLS. These findings suggest that RNA processing may represent a common pathogenic mechanism involved in development of ALS. In this review, we will discuss six ALS-related, RNA processing genes including their discovery, function, and commonalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.