ArticleJournal of molecular evolution2010
Nematode sbRNAs: homologs of vertebrate Y RNAs.
Article in Journal of molecular evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Age-dependent upregulation of Y RNAs inmicroPublication biology · 2021Article
- Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression.International journal for parasitology · 2020Article
- Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers.Cancers · 2020Review
- Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System.Advances in experimental medicine and biology · 2020Review
- Identification and characterization of stem-bulge RNAs in Drosophila melanogaster.RNA biology · 2019Article
- Circulating Y-RNAs in Extracellular Vesicles and Ribonucleoprotein Complexes; Implications for the Immune System.Frontiers in immunology · 2018Review
- SMORE: Synteny Modulator of Repetitive Elements.Life (Basel, Switzerland) · 2017Article
- Shortcuts to a functional adipose tissue: The role of small non-coding RNAs.Redox biology · 2017Review
- RNAlien - Unsupervised RNA family model construction.Nucleic acids research · 2016Article
- Functional roles of non-coding Y RNAs.The international journal of biochemistry & cell biology · 2015Review
- Non-coding stem-bulge RNAs are required for cell proliferation and embryonic development in C. elegans.Journal of cell science · 2015Article
- Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.Nature communications · 2014Article
- pY RNA1-s2: a highly retina-enriched small RNA that selectively binds to Matrin 3 (Matr3).PloS one · 2014Article
- A differential sequencing-based analysis of the C. elegans noncoding transcriptome.RNA (New York, N.Y.) · 2012Article
- Homology-based annotation of non-coding RNAs in the genomes of Schistosoma mansoni and Schistosoma japonicum.BMC genomics · 2009Article
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Authors and funding
8 authors.
Funding
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Abstract
Stem-bulge RNAs (sbRNAs) are a group of small, functionally yet uncharacterized noncoding RNAs first described in C. elegans, with a few homologous sequences postulated in C. briggsae. In this study, we report on a comprehensive survey of this ncRNA family in the phylum Nematoda. Employing homology search strategies based on both sequence and secondary structure models and a computational promoter screen we identified a total of 240 new sbRNA homologs. For the majority of these loci we identified both promoter regions and transcription termination signals characteristic for pol-III transcripts. Sequence and structure comparison with known RNA families revealed that sbRNAs are homologs of vertebrate Y RNAs. Most of the sbRNAs show the characteristic Ro protein binding motif, and contain a region highly similar to a functionally required motif for DNA replication previously thought to be unique to vertebrate Y RNAs. The single Y RNA that was previously described in C. elegans, however, does not show this motif, and in general bears the hallmarks of a highly derived family member.
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