Trial reportJournal of dental research2010
Doxycycline effects on serum bone biomarkers in post-menopausal women.
Trial report in Journal of dental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00066027 (Low-Dose Doxycycline Effects on Osteopenic Bone Loss), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-Dose Doxycycline Effects on Osteopenic Bone Loss
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis.The Cochrane database of systematic reviews · 2018Pooled it
- The effect of choline-stabilized orthosilicic acid in patients with peri-implantitis: an exploratory randomized, double-blind, placebo controlled study.BMC oral health · 2021Trial
- Serum bone biomarkers and oral/systemic bone loss in humans.Journal of dental research · 2011Trial
- The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial.Journal of the American Dental Association (1939) · 2011Trial
- MicroRNA-101a enhances trabecular bone accrual in male mice.Scientific reports · 2022Article
- Periodontal therapeutics: Current host-modulation agents and future directions.Periodontology 2000 · 2020Review
- Doxycycline reduces osteopenia in female rats.Scientific reports · 2019Article
- Loss of alveolar bone density in postmenopausal, osteopenic women is associated with circulating levels of gelatinases.Journal of periodontal research · 2019Article
- Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases.International dental journal · 2016Review
- A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations.Mediators of inflammation · 2014Article
- Anti-inflammatory Actions of Adjunctive Tetracyclines and Other Agents in Periodontitis and Associated Comorbidities.The open dentistry journal · 2014Article
- Perioceutics: Matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease.Journal of pharmacy & bioallied sciences · 2012Article
- Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine.Journal of oral microbiology · 2012Article
- Using tetracyclines to treat osteoporotic/osteopenic bone loss: from the basic science laboratory to the clinic.Pharmacological research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease progression, and biomarkers of collagen destruction and bone resorption locally in periodontal pockets, in a double-blind placebo-controlled clinical trial. We now hypothesize that SDD may also improve biomarkers of bone loss systemically in the same women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and animal models of bone-deficiency disease. 128 post-menopausal osteopenic women with chronic periodontitis randomly received SDD or placebo tablets daily for 2 years adjunctive to periodontal maintenance therapy every 3-4 months. Blood was collected at baseline and at one- and two-year appointments, and sera were analyzed for bone resorption and bone formation/turnover biomarkers. In subsets of the study population, adjunctive SDD significantly reduced serum biomarkers of bone resorption (biomarkers of bone formation were unaffected), consistent with reduced risk of future systemic bone loss in these post-menopausal women not yet on anti-osteoporotic drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.