ArticleThe Plant cell2010
Alkylresorcinol synthases expressed in Sorghum bicolor root hairs play an essential role in the biosynthesis of the allelopathic benzoquinone sorgoleone.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 94 citations in OpenAlex.
- Plant metabolic adaptation to nitrogen scarcity: the role of biological nitrification inhibitors.Essays in biochemistry · 2026Review
- Synthetic Biology Toolbox for Nitrogen-Fixing Soil Microbes.ACS synthetic biology · 2023Article
- Characteristic of the gene candidate SecARS encoding alkylresorcinol synthase in Secale.Molecular biology reports · 2023Article
- Variation on a theme: the structures and biosynthesis of specialized fatty acid natural products in plants.The Plant journal : for cell and molecular biology · 2022Review
- Article
- Sorghum breeding in the genomic era: opportunities and challenges.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- In vivo assembly of the sorgoleone biosynthetic pathway and its impact on agroinfiltrated leaves of Nicotiana benthamiana.The New phytologist · 2021Article
- The Sorghum bicolor Root Exudate Sorgoleone Shapes Bacterial Communities and Delays Network Formation.mSystems · 2021Article
- An Overview of the Medicinally Important Plant Type III PKS Derived Polyketides.Frontiers in plant science · 2021Review
- Lipopolysaccharides trigger synthesis of the allelochemical sorgoleone in cell cultures ofPlant signaling & behavior · 2020Article
- Article
- Complex Patterns of Cannabinoid Alkyl Side-Chain Inheritance in Cannabis.Scientific reports · 2019Article
- The Origin and Evolution of Plant Flavonoid Metabolism.Frontiers in plant science · 2019Review
- Progress in Optimization ofInternational journal of molecular sciences · 2018Review
- A cytochrome P450 CYP71 enzyme expressed in Sorghum bicolor root hair cells participates in the biosynthesis of the benzoquinone allelochemical sorgoleone.The New phytologist · 2018Article
- Developmental Plasticity of the Major Alkyl Cannabinoid Chemotypes in a DiverseFrontiers in plant science · 2018Article
- Discriminating the reaction types of plant type III polyketide synthases.Bioinformatics (Oxford, England) · 2017Article
- Transcriptomic insight into terpenoid and carbazole alkaloid biosynthesis, and functional characterization of two terpene synthases in curry tree (Murraya koenigii).Scientific reports · 2017Article
- A Novel Class of Plant Type III Polyketide Synthase Involved in Orsellinic Acid Biosynthesis fromFrontiers in plant science · 2016Article
- Evaluation of Sorghum [Sorghum bicolor (L.)] Reference Genes in Various Tissues and under Abiotic Stress Conditions for Quantitative Real-Time PCR Data Normalization.Frontiers in plant science · 2016Article
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sorghum bicolor is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone, which likely accounts for many of the allelopathic properties of Sorghum spp. Current evidence suggests that sorgoleone biosynthesis occurs exclusively in root hair cells and involves the production of an alkylresorcinolic intermediate (5-[(Z,Z)-8',11',14'-pentadecatrienyl]resorcinol) derived from an unusual 16:3Delta(9,12,15) fatty acyl-CoA starter unit. This led to the suggestion of the involvement of one or more alkylresorcinol synthases (ARSs), type III polyketide synthases (PKSs) that produce 5-alkylresorcinols using medium to long-chain fatty acyl-CoA starter units via iterative condensations with malonyl-CoA. In an effort to characterize the enzymes responsible for the biosynthesis of the pentadecyl resorcinol intermediate, a previously described expressed sequence tag database prepared from isolated S. bicolor (genotype BTx623) root hairs was first mined for all PKS-like sequences. Quantitative real-time RT-PCR analyses revealed that three of these sequences were preferentially expressed in root hairs, two of which (designated ARS1 and ARS2) were found to encode ARS enzymes capable of accepting a variety of fatty acyl-CoA starter units in recombinant enzyme studies. Furthermore, RNA interference experiments directed against ARS1 and ARS2 resulted in the generation of multiple independent transformant events exhibiting dramatically reduced sorgoleone levels. Thus, both ARS1 and ARS2 are likely to participate in the biosynthesis of sorgoleone in planta. The sequences of ARS1 and ARS2 were also used to identify several rice (Oryza sativa) genes encoding ARSs, which are likely involved in the production of defense-related alkylresorcinols.
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