ArticleThe Plant cell2010
Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 183 citations in OpenAlex.
- Identification of candidate genes governing key metabolic pathways in fenugreek (Trigonella spp.) through integrated transcriptomic and metabolomic analysis.Functional & integrative genomics · 2026Article
- Review
- Roles of three cytochrome P450 monooxygenases in triterpene biosynthesis and their potential impact on growth and development.Plant physiology · 2024Article
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- Saponin Biosynthesis in Pulses.Plants (Basel, Switzerland) · 2022Review
- Whole-Genome Identification and Analysis of Multiple Gene Families Reveal Candidate Genes for Theasaponin Biosynthesis inInternational journal of molecular sciences · 2022Article
- The ease and complexity of identifying and using specialized metabolites for crop engineering.Emerging topics in life sciences · 2022Review
- Transcriptomic Analysis of Early Flowering Signals in 'Royal' Flax.Plants (Basel, Switzerland) · 2022Article
- Specific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata.The Plant cell · 2021Article
- Cleaning thePlants (Basel, Switzerland) · 2021Article
- UGT84F9 is the major flavonoid UDP-glucuronosyltransferase in Medicago truncatula.Plant physiology · 2021Article
- Article
- CRISPR/Cas9-Mediated Targeted Mutagenesis ofFrontiers in plant science · 2021Article
- A Seed-Specific Regulator of Triterpene Saponin Biosynthesis inThe Plant cell · 2020Article
- Multiomics-based characterization of specialized metabolites biosynthesis in Cornus Officinalis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2020Article
- Reconstruction of the Evolutionary Histories of UGT Gene Superfamily in Legumes Clarifies the Functional Divergence of Duplicates in Specialized Metabolism.International journal of molecular sciences · 2020Article
- Identification of α-Amyrin 28-Carboxylase and Glycosyltransferase FromFrontiers in plant science · 2020Article
- Identification of key genes involved in the biosynthesis of triterpenic acids in the mint family.Scientific reports · 2019Article
- Ectopic Defense Gene Expression Is Associated with Growth Defects inPlant physiology · 2019Article
- Functional characterization of three flavonoid glycosyltransferases fromRoyal Society open science · 2019Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saponins, an important group of bioactive plant natural products, are glycosides of triterpenoid or steroidal aglycones (sapogenins). Saponins possess many biological activities, including conferring potential health benefits for humans. However, most of the steps specific for the biosynthesis of triterpene saponins remain uncharacterized at the molecular level. Here, we use comprehensive gene expression clustering analysis to identify candidate genes involved in the elaboration, hydroxylation, and glycosylation of the triterpene skeleton in the model legume Medicago truncatula. Four candidate uridine diphosphate glycosyltransferases were expressed in Escherichia coli, one of which (UGT73F3) showed specificity for multiple sapogenins and was confirmed to glucosylate hederagenin at the C28 position. Genetic loss-of-function studies in M. truncatula confirmed the in vivo function of UGT73F3 in saponin biosynthesis. This report provides a basis for future studies to define genetically the roles of multiple cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago.
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