ArticleApplied and environmental microbiology2010
Proteomic analyses to reveal the protective role of glutathione in resistance of Lactococcus lactis to osmotic stress.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 66 citations in OpenAlex.
- Integrated Multiomics Elucidates Glutathione Metabolic Regulation in a Marine Aromatic Probiotic YeastACS omega · 2025Article
- Effect of glutathione-transport-related geneApplied and environmental microbiology · 2024Article
- Fermentation Characteristics, Antinutritional Factor Level and Flavor Compounds of Soybean Whey Yogurt.Foods (Basel, Switzerland) · 2024Article
- Development of chemically defined media for3 Biotech · 2023Article
- Isolation of Aroma-ProducingFoods (Basel, Switzerland) · 2023Article
- Characterization of GshAB of Tetragenococcus halophilus: a two-domain glutathione synthetase.Applied microbiology and biotechnology · 2023Article
- Three Microbial Musketeers of the Seas:International journal of molecular sciences · 2022Article
- Higher nisin yield is reached with glutathione and pyruvate compared with heme in Lactococcus lactis N8.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Comparative proteomic analysis of four biotechnological strains Lactococcus lactis through label-free quantitative proteomics.Microbial biotechnology · 2019Article
- The Progress of Multi-Omics Technologies: Determining Function in Lactic Acid Bacteria Using a Systems Level Approach.Frontiers in microbiology · 2019Review
- Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations.Scientific reports · 2018Article
- Optimization of Reduced Glutathione Production by aFrontiers in microbiology · 2017Article
- Isolation and Analysis of Salt Response ofIndian journal of microbiology · 2016Article
- Metabolic changes in Klebsiella oxytoca in response to low oxidoreduction potential, as revealed by comparative proteomic profiling integrated with flux balance analysis.Applied and environmental microbiology · 2014Article
- Growth phase-dependent proteomes of the Malaysian isolated Lactococcus lactis dairy strain M4 using label-free qualitative shotgun proteomics analysis.TheScientificWorldJournal · 2014Article
- Discovery of a novel gene involved in autolysis of Clostridium cells.Protein & cell · 2013Article
- Current status and emerging role of glutathione in food grade lactic acid bacteria.Microbial cell factories · 2012Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we have shown that glutathione can protect Lactococcus lactis against oxidative stress and acid stress. In this study, we show that glutathione taken up by L. lactis SK11 can protect this organism against osmotic stress. When exposed to 5 M NaCl, L. lactis SK11 cells containing glutathione exhibited significantly improved survival compared to the control cells. Transmission electron microscopy showed that the integrity of L. lactis SK11 cells containing glutathione was maintained for at least 24 h, whereas autolysis of the control cells occurred within 2 h after exposure to this osmotic stress. Comparative proteomic analyses using SK11 cells containing or not containing glutathione that were exposed or not exposed to osmotic stress were performed. The results revealed that 21 of 29 differentially expressed proteins are involved in metabolic pathways, mainly sugar metabolism. Several glycolytic enzymes of L. lactis were significantly upregulated in the presence of glutathione, which might be the key for improving the general stress resistance of a strain. Together with the results of previous studies, the results of this study demonstrated that glutathione plays important roles in protecting L. lactis against multiple environmental stresses; thus, glutathione can be considered a general protectant for improving the robustness and stability of dairy starter cultures.
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