ArticleToxicological sciences : an official journal of the Society of Toxicology2010
Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Review
- Genome-wide identification of PAR domain protein 1 (PDP1) targets through ChIP-seq reveals the regulation of diapause-specific characteristics in Culex pipiens.Insect molecular biology · 2024Article
- Soil and water pollution and human health: what should cardiologists worry about?Cardiovascular research · 2023Review
- Redox Regulatory Changes of Circadian Rhythm by the Environmental Risk Factors Traffic Noise and Air Pollution.Antioxidants & redox signaling · 2022Review
- Molecular Oscillator Affects Susceptibility of Caterpillars to Insecticides: Studies on the Egyptian Cotton Leaf Worm-Insects · 2022Article
- Circadian regulation of night feeding and daytime detoxification in a formidable Asian pest Spodoptera litura.Communications biology · 2021Article
- Time of Day-Specific Changes in Metabolic Detoxification and Insecticide Tolerance in the House Fly,Frontiers in physiology · 2021Article
- Influence of mental stress and environmental toxins on circadian clocks: Implications for redox regulation of the heart and cardioprotection.British journal of pharmacology · 2020Review
- Transposable elements contribute to the genomic response to insecticides inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- High-resolution QTL mapping in Tetranychus urticae reveals acaricide-specific responses and common target-site resistance after selection by different METI-I acaricides.Insect biochemistry and molecular biology · 2019Article
- The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes.PLoS pathogens · 2019Article
- Circadian regulation of metabolism and healthspan in Drosophila.Free radical biology & medicine · 2018Review
- De novo transcriptome assembly of brackish water fleaHereditas · 2018Article
- Improved statistical methods enable greater sensitivity in rhythm detection for genome-wide data.PLoS computational biology · 2015Article
- Aging alters circadian regulation of redox in Drosophila.Frontiers in genetics · 2015Article
- Article
- Chronopharmacology: new insights and therapeutic implications.Annual review of pharmacology and toxicology · 2014Review
- Aging signaling pathways and circadian clock-dependent metabolic derangements.Trends in endocrinology and metabolism: TEM · 2013Review
- Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides.PloS one · 2013Article
- Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.Neurobiology of disease · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Daily rhythms generated by the circadian clock regulate many life functions, including responses to xenobiotic compounds. In Drosophila melanogaster, the circadian clock consists of positive elements encoded by cycle (cyc) and Clock (Clk) and negative elements encoded by period (per) and timeless (tim) genes. The epsilon-isoform of the PAR-domain protein 1 (Pdp1epsilon) transcription factor is controlled by positive clock elements and regulates daily locomotor activity rhythms. Pdp1 target genes have not been identified, and its involvement in other clock output pathways is not known. Mammalian orthologs of Pdp1 have been implicated in the regulation of xenobiotic metabolism; therefore, we asked whether Pdp1 has a similar role in the fly. Using pesticides as model toxicants, we determined that disruption of Pdp1epsilon increased pesticide-induced mortality in flies. Flies deficient for cyc also showed increased mortality, while disruption of per and tim had no effect. Day/night and Pdp1-dependent differences in the expression of xenobiotic-metabolizing enzymes Cyp6a2, Cyp6g1, and alpha-Esterase-7 were observed and likely contribute to impaired detoxification. DHR96, a homolog of constitutive androstane receptor and pregnane X receptor, is involved in pesticide response, and DHR96 expression decreased when Pdp1 was suppressed. Taken together, our data uncover a pathway from the positive arm of the circadian clock through Pdp1 to detoxification effector genes, demonstrating a conserved role of the circadian system in modulating xenobiotic toxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.