SynthesisInternational journal of epidemiology2010
The effect of oral rehydration solution and recommended home fluids on diarrhoea mortality.
Synthesis in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04335877 (Effectiveness-Implementation Research to Assess the Effect of Prompting the Supply of Zinc/LO-ORS Co-packs Through the Private Sector Coupled With Behavior Change Intervention on the Treatment of Uncomplicated Childhood Diarrhoea in Kenya), which is not on this map. Cited by 142 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness-Implementation Research to Assess the Effect of Prompting the Supply of Zinc/LO-ORS Co-packs Through the Private Sector Coupled With Behavior Change Intervention on the Treatment of Uncomplicated Childhood Diarrhoea in Kenya
Who cites it
142 citing papers in PubMed, 11 syntheses or guidelines pooled it, 312 citations in OpenAlex.
- Global childhood diarrhoea prevalence and its determinants: a systematic meta-analytic assessment, 1985-2024.EBioMedicine · 2025Pooled it
- Low-osmolarity oral rehydration solution for childhood diarrhoea: A systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Vitamin DBMC infectious diseases · 2023Pooled it
- Global Estimates of Rotavirus Hospitalizations Among Children Below 5 Years in 2019 and Current and Projected Impacts of Rotavirus Vaccination.Journal of the Pediatric Infectious Diseases Society · 2022Pooled it
- Barriers and facilitators to implementation of oral rehydration therapy in low- and middle-income countries: A systematic review.PloS one · 2021Pooled it
- Ending malnutrition in all its forms requires scaling up proven nutrition interventions and much more: a 129-country analysis.BMC medicine · 2020Pooled it
- Cost of illness for childhood diarrhea in low- and middle-income countries: a systematic review of evidence and modelled estimates.BMC public health · 2020Pooled it
- Quantifying the indirect effects of key child survival interventions for pneumonia, diarrhoea, and measles.Epidemiology and infection · 2013Pooled it
- Systematic review of strategies to increase use of oral rehydration solution at the household level.BMC public health · 2013Pooled it
- The effect of rotavirus vaccine on diarrhoea mortality.International journal of epidemiology · 2010Pooled it
- Diarrhea as a Disease of Poverty Among Under-Five Children in Sub-Saharan Africa: A Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingPooled it
- A cross-sectional analysis of the impact of lady health worker visits in the prenatal and postnatal period on the uptake of continuum of care interventions and childhood mortality in Pakistan.Journal of global health · 2025Trial
- The cost-effectiveness of community health workers delivering free diarrhoea treatment: evidence from Uganda.Health policy and planning · 2022Trial
- The role of price and convenience in use of oral rehydration salts to treat child diarrhea: A cluster randomized trial in Uganda.PLoS medicine · 2019Trial
- Caregiver oral rehydration solution fluid monitoring charts versus standard care for the management of some dehydration among Kenyan children: a randomized controlled trial.International health · 2018Trial
- Disentangling the effects of a multiple behaviour change intervention for diarrhoea control in Zambia: a theory-based process evaluation.Globalization and health · 2017Trial
- Theory-based formative research on oral rehydration salts and zinc use in Lusaka, Zambia.BMC public health · 2016Trial
- Right-sizing Incentives.Journal of development economics · 2026Article
- Pharmacological assessment of drugs retained in the 1Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Trends and burden of diarrhoeal diseases across India, 1990 - 2023: A systematic analysis from the global burden of disease study 2023.New microbes and new infections · 2026Article
82 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMost diarrhoeal deaths can be prevented through the prevention and treatment of dehydration. Oral rehydration solution (ORS) and recommended home fluids (RHFs) have been recommended since 1970s and 1980s to prevent and treat diarrhoeal dehydration. We sought to estimate the effects of these interventions on diarrhoea mortality in children aged <5 years.
methodsWe conducted a systematic review to identify studies evaluating the efficacy and effectiveness of ORS and RHFs and abstracted study characteristics and outcome measures into standardized tables. We categorized the evidence by intervention and outcome, conducted meta-analyses for all outcomes with two or more data points and graded the quality of the evidence supporting each outcome. The CHERG Rules for Evidence Review were used to estimate the effectiveness of ORS and RHFs against diarrhoea mortality.
resultsWe identified 205 papers for abstraction, of which 157 were included in the meta-analyses of ORS outcomes and 12 were included in the meta-analyses of RHF outcomes. We estimated that ORS may prevent 93% of diarrhoea deaths.
conclusionsORS is effective against diarrhoea mortality in home, community and facility settings; however, there is insufficient evidence to estimate the effectiveness of RHFs against diarrhoea mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.