SynthesisInternational journal of epidemiology2010
Effectiveness of measles vaccination and vitamin A treatment.
Synthesis in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review.The Journal of nutrition · 2021Pooled it
- Quantifying the indirect effects of key child survival interventions for pneumonia, diarrhoea, and measles.Epidemiology and infection · 2013Pooled it
- Trial
- Effect of multivitamin supplementation on measles vaccine response among HIV-exposed uninfected Tanzanian infants.Clinical and vaccine immunology : CVI · 2013Trial
- Estimating the basic reproduction number of measles in low-and middle-income settings using 172 seroprevalence studies: A modelling approach.PLOS global public health · 2026Article
- The cost of inaction to strengthen the resilience of primary health care in Latin America and the Caribbean: a modelling study.Lancet regional health. Americas · 2025Article
- Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children.PLoS computational biology · 2025Article
- Inequalities in diarrhoea, pneumonia and measles deaths: estimates for 21 sub-Saharan African countries.Bulletin of the World Health Organization · 2025Article
- Article
- Vitamin A and Its Related Diseases.Food science & nutrition · 2025Review
- High measles and rubella vaccine coverage and seroprevalence among Zambian children participating in a measles and rubella supplementary immunization activity.PLOS global public health · 2025Article
- Dietary Modulation of the Immune System.Nutrients · 2024Review
- Inequalities in measles immunization coverage among two-year-olds in Sierra Leone, 2008-2019.BMC infectious diseases · 2024Article
- How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024Review
- Measles resurgence in Armenia: unmasking health system vulnerabilities and crafting comprehensive eradication strategies - a review.Annals of medicine and surgery (2012) · 2024Review
- Using the Lives Saved Tool to inform global nutrition advocacy.Journal of global health · 2024Article
- Impact and cost-effectiveness of measles vaccination through microarray patches in 70 low-income and middle-income countries: mathematical modelling and early-stage economic evaluation.BMJ global health · 2023Article
- Measles: Contemporary considerations for the emergency physician.Journal of the American College of Emergency Physicians open · 2023Review
- Health effects of routine measles vaccination and supplementary immunisation activities in 14 high-burden countries: a Dynamic Measles Immunization Calculation Engine (DynaMICE) modelling study.The Lancet. Global health · 2023Article
- Carotenoids: Role in Neurodegenerative Diseases Remediation.Brain sciences · 2023Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current strategy utilized by WHO/United Nations Children's Fund (UNICEF) to reach the Global Immunization Vision and Strategy 2010 measles reduction goal includes increasing coverage of measles vaccine, vitamin A treatment and supplementation in addition to offering two doses of vaccine to all children.
methodsWe conducted a systematic review of published randomized controlled trials (RCTs) and quasi-experimental (QE) studies in order to determine effect estimates of measles vaccine and vitamin A treatment for the Lives Saved Tool (LiST). We utilized a standardized abstraction and grading format in order to determine effect estimates for measles mortality employing the standard Child Health Epidemiology Research Group Rules for Evidence Review.
resultsWe identified three measles vaccine RCTs and two QE studies with data on prevention of measles disease. A meta-analysis of these studies found that vaccination was 85% [95% confidence interval (CI) 83-87] effective in preventing measles disease, which will be used as a proxy for measles mortality in LiST for countries vaccinating before one year of age. The literature also suggests that a conservative 95% effect estimate is reasonable to employ when vaccinating at 1 year or later and 98% for two doses of vaccine based on serology reviews. We included six high-quality RCTs in the meta-analysis of vitamin A treatment of measles which found no significant reduction in measles morality. However, when stratifying by vitamin A treatment dose, at least two doses were found to reduce measles mortality by 62% (95% CI 19-82).
conclusionMeasles vaccine and vitamin A treatment are effective interventions to prevent measles mortality in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.