SynthesisInternational journal of epidemiology2010
Antibiotics for pre-term pre-labour rupture of membranes: prevention of neonatal deaths due to complications of pre-term birth and infection.
Synthesis in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Developing a Core Outcome Set for the Evaluation of Antibiotic Use in Prelabor Rupture of Membranes: A Systematic Review and Semi-Structured Interview.Frontiers in pharmacology · 2022Pooled it
- Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis.PLoS medicine · 2013Pooled it
- Care during labor and birth for the prevention of intrapartum-related neonatal deaths: a systematic review and Delphi estimation of mortality effect.BMC public health · 2011Pooled it
- Clean birth and postnatal care practices to reduce neonatal deaths from sepsis and tetanus: a systematic review and Delphi estimation of mortality effect.BMC public health · 2011Pooled it
- Antenatal interventions to support newborn survival: updates for the Lives Saved Tool.Journal of global health · 2026Article
- Maintenance tocolysis in twin pregnancies after preterm premature rupture of membranes and neonatal outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Cesarean section and pregnancy outcomes of preterm premature rupture of membranes under different fertility policies in China.Translational pediatrics · 2021Article
- Cesarean section does not affect neonatal outcomes of pregnancies complicated with preterm premature rupture of membranes.Chinese medical journal · 2020Article
- A cost-effectiveness analysis of maternal and neonatal health interventions in Ethiopia.Health policy and planning · 2019Article
- Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin.BMC medicine · 2018Article
- 'First 1000 days' health interventions in low- and middle-income countries: alignment of South African policies with high-quality evidence.Global health action · 2017Article
- Antibiotic Therapy for Chorioamnionitis to Reduce the Global Burden of Associated Disease.Frontiers in pharmacology · 2017Review
- Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.British journal of clinical pharmacology · 2016Article
- Interventions to Improve Neonatal Health and Later Survival: An Overview of Systematic Reviews.EBioMedicine · 2015Review
- Miracle baby: managing extremely preterm birth in rural Uganda.BMJ case reports · 2014Article
- Essential interventions: implementation strategies and proposed packages of care.Reproductive health · 2014Article
- Essential pre-pregnancy and pregnancy interventions for improved maternal, newborn and child health.Reproductive health · 2014Review
- Paradoxical trends and racial differences in obstetric quality and neonatal and maternal mortality.Obstetrics and gynecology · 2013Article
- Born too soon: care during pregnancy and childbirth to reduce preterm deliveries and improve health outcomes of the preterm baby.Reproductive health · 2013Review
- Neonatal outcomes are associated with latency after preterm premature rupture of membranes.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn high-income countries, it is standard practice to give antibiotics to women with pre-term, pre-labour rupture of membranes (pPROM) to delay birth and reduce the risk of infection. In low and middle-income settings, where some 2 million neonatal deaths occur annually due to complications of pre-term birth or infection, many women do not receive antibiotic therapy for pPROM.
objectivesTo review the evidence for and estimate the effect on neonatal mortality due to pre-term birth complications or infection, of administration of antibiotics to women with pPROM, in low and middle-income countries.
methodsWe performed a systematic review to update a Cochrane review. Standardized abstraction forms were used. The quality of the evidence provided by individual studies and overall was assessed using an adapted GRADE approach.
resultsEighteen RCTs met our inclusion criteria. Most were from high-income countries and provide strong evidence that antibiotics for pPROM reduce the risk of respiratory distress syndrome [risk ratio (RR) = 0.88; confidence interval (CI) 0.80, 0.97], and early onset postnatal infection (RR = 0.61; CI 0.48, 0.77). The data are consistent with a reduction in neonatal mortality (RR = 0.90; CI 0.72, 1.12).
conclusionAntibiotics for pPROM reduce complications due to pre-term delivery and post-natal infection in high-income settings. There is moderate quality evidence that, in low-income settings, where access to other interventions (antenatal steroids, surfactant therapy, ventilation, antibiotic therapy) may be low, antibiotics for pPROM could prevent 4% of neonatal deaths due to complications of prematurity and 8% of those due to infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.