ReviewBiochimica et biophysica acta2010
Lipid packing determines protein-membrane interactions: challenges for apolipoprotein A-I and high density lipoproteins.
Review in Biochimica et biophysica acta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Studying biological events using biopolymeric matrices.Biophysical reviews · 2025Review
- Cell-free, high-density lipoprotein-specific phospholipid efflux assay predicts incident cardiovascular disease.The Journal of clinical investigation · 2023Article
- Effect of Anionic Lipids on Mammalian Plasma Cell Membrane Properties.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Peptide-Membrane Interactions Monitored by Fluorescence Lifetime Imaging: A Study Case of Transportan 10.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- LAURDAN since Weber: The Quest for Visualizing Membrane Heterogeneity.Accounts of chemical research · 2021Article
- Plasma membrane vesicles from cauliflower meristematic tissue and their role in water passage.BMC plant biology · 2021Article
- CAPRYDAA, an anthracene dye analog to LAURDAN: a comparative study using cuvette and microscopy.Journal of materials chemistry. B · 2020Article
- Cardiolipin-Dependent Properties of Model Mitochondrial Membranes from Molecular Simulations.Biophysical journal · 2019Article
- Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I.Scientific reports · 2018Article
- Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy.Biophysical journal · 2017Article
- Regulation of Connexin-Based Channels by Fatty Acids.Frontiers in physiology · 2017Review
- Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers.Analytical chemistry · 2015Article
- TrackArt: the user friendly interface for single molecule tracking data analysis and simulation applied to complex diffusion in mica supported lipid bilayers.BMC research notes · 2014Article
- Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases.Acta biochimica et biophysica Sinica · 2014Article
- A major role for RCAN1 in atherosclerosis progression.EMBO molecular medicine · 2013Article
- The chemical nature of the polar functional group of oxidized acyl chain uniquely modifies the physicochemical properties of oxidized phospholipid-containing lipid particles.The Journal of membrane biology · 2013Article
- Laurdan generalized polarization fluctuations measures membrane packing micro-heterogeneity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Imaging lipid lateral organization in membranes with C-laurdan in a confocal microscope.Journal of lipid research · 2012Article
- Methyl-β-cyclodextrins preferentially remove cholesterol from the liquid disordered phase in giant unilamellar vesicles.The Journal of membrane biology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Protein and protein-lipid interactions, with and within specific areas in the cell membrane, are critical in order to modulate the cell signaling events required to maintain cell functions and viability. Biological bilayers are complex, dynamic platforms, and thus in vivo observations usually need to be preceded by studies on model systems that simplify and discriminate the different factors involved in lipid-protein interactions. Fluorescence microscopy studies using giant unilamellar vesicles (GUVs) as membrane model systems provide a unique methodology to quantify protein binding, interaction, and lipid solubilization in artificial bilayers. The large size of lipid domains obtainable on GUVs, together with fluorescence microscopy techniques, provides the possibility to localize and quantify molecular interactions. Fluorescence Correlation Spectroscopy (FCS) can be performed using the GUV model to extract information on mobility and concentration. Two-photon Laurdan Generalized Polarization (GP) reports on local changes in membrane water content (related to membrane fluidity) due to protein binding or lipid removal from a given lipid domain. In this review, we summarize the experimental microscopy methods used to study the interaction of human apolipoprotein A-I (apoA-I) in lipid-free and lipid-bound conformations with bilayers and natural membranes. Results described here help us to understand cholesterol homeostasis and offer a methodological design suited to different biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.