ReviewSeminars in nephrology2010
Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection.
Review in Seminars in nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.Human genomics · 2022Pooled it
- Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.Pharmacogenetics and genomics · 2018Pooled it
- Trial
- Genetic and epigenetic background of diabetic kidney disease.Frontiers in endocrinology · 2023Review
- Multidrug resistance-associated protein 4 (Mrp4) is a novel genetic factor in the pathogenesis of obesity and diabetes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Diabetic Kidney Disease: Challenges, Advances, and Opportunities.Kidney diseases (Basel, Switzerland) · 2020Review
- Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease.Molecular medicine reports · 2018Article
- Progress in Defining the Genetic Basis of Diabetic Complications.Current diabetes reports · 2017Review
- Aquaporin 11 variant associates with kidney disease in type 2 diabetic patients.American journal of physiology. Renal physiology · 2016Article
- Vitamin E and diabetic nephropathy in mice model and humans.World journal of nephrology · 2013Review
- HLA class II genotyping of African American type 1 diabetic patients reveals associations unique to African haplotypes.Diabetes · 2013Article
- Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus.Free radical biology & medicine · 2012Article
- Perspectives on systems biology applications in diabetic kidney disease.Journal of cardiovascular translational research · 2012Review
- Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes.Molecular genetics and metabolism · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The Genetics of Kidneys in Diabetes (GoKinD) study was initiated to facilitate research aimed at identifying genes involved in diabetic nephropathy (DN) in type 1 diabetes. In this review, we present an overview of this study and the various reports that have used its collection. At the forefront of these efforts is the recent genome-wide association scan implemented on the GoKinD collection. We highlight the results from our analysis of these data and describe compelling evidence from animal models that further support the potential role of associated loci in the susceptibility of DN. To enhance our analysis of genetic associations in GoKinD, using genome-wide imputation, we expanded our analysis of this collection to include genotype data from more than 2.4 million common single nucleotide polymorphisms. We illustrate the added utility of this enhanced dataset through the comprehensive fine-mapping of candidate genomic regions previously linked with DN and the targeted investigation of genes involved in candidate pathways implicated in its pathogenesis. Collectively, genome-wide association and genome-wide imputation data from the GoKinD collection will serve as a springboard for future investigations into the genetic basis of DN in type 1 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.