ArticleBiomaterials2010
A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Application of ultrasound and ultrasound-responsive materials in wounds: A systematic review.International journal of pharmaceutics: X · 2026Review
- Ultrasound-responsive hydrogels for bone and cartilage tissue engineering.Materials today. Bio · 2025Review
- Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system.Advanced drug delivery reviews · 2024Review
- Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives.Bioactive materials · 2024Review
- Intelligent Hydrogel-Assisted Hepatocellular Carcinoma Therapy.Research (Washington, D.C.) · 2024Review
- Controlled Drug Release from Nanoengineered Polysaccharides.Pharmaceutics · 2023Review
- Structural and mechanical properties of folded protein hydrogels with embedded microbubbles.Biomaterials science · 2023Article
- Biomimicry in nanotechnology: a comprehensive review.Nanoscale advances · 2023Review
- Controlled Delivery of Corticosteroids Using Tunable Tough Adhesives.Advanced healthcare materials · 2023Article
- MnONanoscale advances · 2022Article
- Ultrasound-Induced Drug Release from Stimuli-Responsive Hydrogels.Gels (Basel, Switzerland) · 2022Review
- Ultrasound-Responsive Hydrogels for On-Demand Protein Release.ACS applied bio materials · 2022Article
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
- Ultrasound Triggered Drug Release from Affinity-Based β-Cyclodextrin Polymers for Infection Control.Annals of biomedical engineering · 2021Article
- Improving Release of Liposome-Encapsulated Drugs with Focused Ultrasound and Vaporizable Droplet-Liposome Nanoclusters.Pharmaceutics · 2021Article
- Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery.Journal of biomaterials science. Polymer edition · 2021Article
- Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses.Scientific reports · 2019Article
- Parametric Study of Acoustic Droplet Vaporization Thresholds and Payload Release From Acoustically-Responsive Scaffolds.Ultrasound in medicine & biology · 2019Article
- Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.