ArticleAtencion primaria2010
[Early diagnosis of streptococcal pharyngitis in paediatric practice: Validity of a rapid antigen detection test].
Article in Atencion primaria, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.
- Comparison of Centor and McIsaac scores in primary care: a meta-analysis over multiple thresholds.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Pooled it
- Rapid antigen detection test for group A streptococcus in children with pharyngitis.The Cochrane database of systematic reviews · 2016Pooled it
- Rapid antigen group A streptococcus test to diagnose pharyngitis: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Retrospective study of group A Streptococcus oropharyngeal infection diagnosis using a rapid antigenic detection test in a paediatric population from the central region of Portugal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- [Detección de Streptococcus pyogenes en muestras faringoamigdalares mediante técnica de detección de antígeno].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2020Article
- [Utility of clinical criteria for the adequate diagnosis of the pharingoamigdalitis in the pediatric emergency service].Revista espanola de salud publica · 2019Article
- Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- [Consensus document on the diagnosis and treatment of acute tonsillopharyngitis].Anales de pediatria (Barcelona, Spain : 2003) · 2011Article
- Diagnosis and management of acute pharyngitis in a paediatric population: a cost-effectiveness analysis.European journal of pediatrics · 2011Article
- [Does a pharyngeal culture have to be requested when using rapid antigen techniques?].Atencion primaria · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the validity of the rapid antigen test for the diagnoses of acute pharyngitis caused by group A beta-haemolytic Streptococcus (GABHS) compared with culture.
designObservational study of a consecutive sample of paediatric patients.
settingTwo primary care centres (PCC) from the metropolitan area of Barcelona.
participantsChildren aged 1-14 years with sore throat of no more than 5 days duration were chosen at PCC. PRINCIPAL MEASUREMENTS: Oropharyngeal samples were collected from tonsillar bed and posterior pharynx. A rapid diagnostic test was performed, as well as a throat culture.
resultsA total of 211 patients were studied. The overall prevalence of pharyngitis due to Streptococcus was 34.1%. Compared with the throat culture, the sensitivity of the rapid test was 90.3% (95% CI: 81.0-96.0), the specificity was 78.4% (95% CI: 70.6-84.9). The percentage of false negatives was 9.7% and the false positives was 21.6%. Spectrum bias was present, inasmuch as the rapid test sensitivity increased with Centor scores.
conclusionsThe diagnostic value of a rapid antigen test for the diagnosis of streptococcal pharyngitis in paediatric patients at PCC is high. However, the percentage of false positives and negatives is too high, and also the sensitivity is too low in patients with fewer symptoms to support the use of rapid antigenic test without culture confirmation and bacterial sensitivity test.
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