ArticleProceedings of the National Academy of Sciences of the United States of America1991
Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Secreted Protein Acidic and Rich in Cysteine in Ocular Tissue.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2015Review
- Notch signaling activation suppresses v-Src-induced transformation of neural cells by restoring TGF-β-mediated differentiation.PloS one · 2010Article
- Identification of genes differentially expressed in dorsal and ventral chick midbrain during early development.BMC developmental biology · 2009Article
- Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.The Journal of biological chemistry · 2008Article
- Characterization of Smoc-1 uncovers two transcript variants showing differential tissue and age specific expression in Bubalus bubalis.BMC genomics · 2007Article
- Stable expression of intracellular Notch suppresses v-Src-induced transformation in avian neural cells.Oncogene · 2007Article
- Secreted modular calcium-binding protein-1 localization during mouse embryogenesis.Histochemistry and cell biology · 2006Article
- Characterization of SMOC-2, a modular extracellular calcium-binding protein.The Biochemical journal · 2003Article
- Phosphorylation of MafA is essential for its transcriptional and biological properties.Molecular and cellular biology · 2001Article
- Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways.Molecular and cellular biology · 2000Article
- Characterization of a novel quiescence responsive element downregulated by v-Src in the promoter of the neuroretina specific QR1 gene.Oncogene · 2000Article
- Osteonectin/SPARC secreted by RPE and localized to the outer plexiform layer of the monkey retina.Investigative ophthalmology & visual science · 2000Article
- Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.Molecular vision · 2000Article
- Extracellular matrix-associated protein Sc1 is not essential for mouse development.Molecular and cellular biology · 2000Article
- Identification of an intronic enhancer that nullifies upstream repression of SPARC gene expression.Nucleic acids research · 1997Article
- Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.The EMBO journal · 1997Article
- Structure of a novel extracellular Ca(2+)-binding module in BM-40.Nature structural biology · 1996Article
- Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein.Molecular and cellular biology · 1995Article
- Developmental control of transcription of a retina-specific gene, QR1, during differentiation: involvement of factors from the POU family.Molecular and cellular biology · 1995Article
- The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.Molecular biology of the cell · 1993Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating neuroectodermal precursors that differentiate after terminal mitosis and become organized in cell strata. Genes that are specifically expressed at the various stages of retinal development are presently unknown. We have isolated a quail (Coturnix coturnix japonica) cDNA clone, named QR1, encoding a 676-amino acid protein whose carboxyl-terminal portion shows significant similarity to those of the extracellular glycoprotein osteonectin/SPARC/BM40 and of the recently described SC1 protein. The QR1 cDNA identifies a mRNA detected in NR but not in other embryonic tissues examined. The levels of this mRNA are markedly reduced when nondividing NR cells are induced to proliferate by the v-src oncogene. QR1 expression in NR is limited to the middle portion of the inner nuclear layer, a localization that essentially corresponds to that of Müller cells. Transcription of QR1 takes place only during the late phase of retinal development and is shut off sharply at hatching. Signals that regulate this unique pattern of expression appear to originate within the NR, since the QR1 mRNA is transcribed in cultured NR cells and is shut off also in vitro at a time coinciding with hatching.
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