ArticleImmunity2010
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Article in Immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.Immunology · 2012Pooled it
- A B7-H3-Targeted CD28 Bispecific Antibody Enhances the Activity of Anti-PD-1 and CD3 T-cell Engager Immunotherapies.Molecular cancer therapeutics · 2025Article
- Review
- Inhibition of B cell receptor signaling induced by the human adenovirus species D E3/49K protein.Frontiers in immunology · 2024Article
- Recent advances and applications of CRISPR-Cas9 in cancer immunotherapy.Molecular cancer · 2023Review
- Regulating the discriminatory response to antigen by T-cell receptor.Bioscience reports · 2022Review
- Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma.Frontiers in oncology · 2022Article
- T cell receptor (TCR) signaling in health and disease.Signal transduction and targeted therapy · 2021Review
- Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor.Frontiers in immunology · 2021Article
- The role of competing mechanisms on Lck regulation.Immunologic research · 2020Review
- Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy.Frontiers in cell and developmental biology · 2020Review
- CD45 functions as a signaling gatekeeper in T cells.Science signaling · 2019Article
- mTOR and other effector kinase signals that impact T cell function and activity.Immunological reviews · 2019Review
- Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.Cell reports · 2019Article
- The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.Science immunology · 2019Article
- Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.Nature communications · 2018Article
- Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets.Cell · 2018Article
- Article
- TCR Signaling: Mechanisms of Initiation and Propagation.Trends in biochemical sciences · 2018Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The kinase-phosphatase pair Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn. T cell receptor (TCR) signaling and thymic development require CD45 expression but proceed constitutively in the absence of Csk. Here, we show that relative titration of CD45 and Csk expression reveals distinct regulation of basal and inducible TCR signaling during thymic development. Low CD45 expression is sufficient to rescue inducible TCR signaling and positive selection, whereas high expression is required to reconstitute basal TCR signaling and beta selection. CD45 has a dual positive and negative regulatory role during inducible but not basal TCR signaling. By contrast, Csk titration regulates basal but not inducible signaling. High physiologic expression of CD45 is thus required for two reasons-to downmodulate inducible TCR signaling during positive selection and to counteract Csk during basal TCR signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.