Evidence map›Paper›PMID 20346770›Full record

ArticleImmunity2010

Interleukin-18 in intestinal inflammation: friend and foe?

Britta Siegmund

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2022
    Article
  4. Article
  5. ProphylacticGut microbes · 2020
    Article
  6. Article
  7. Isoflavones and inflammatory bowel disease.World journal of clinical cases · 2020
    Review
  8. Article
  9. Review
  10. Cytokine response after stimulation of culture cells by zinc and probiotic strain.In vitro cellular & developmental biology. Animal · 2019
    Article
  11. Role of NLRP3 inflammasome in inflammatory bowel diseases.World journal of gastroenterology · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Britta SiegmundCharité Universitätsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik I, Hindenburgdamm 30, Berlin, Germany. britta.siegmund@charite.de

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells.

Indexed as

AnimalsCarrier ProteinsCaspase 1Caspase 12ColitisEpithelial CellsHumansInterleukin-18MiceNLR Family, Pyrin Domain-Containing 3 ProteinCarrier ProteinsCaspase 1Caspase 12Interleukin-18NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.