ArticleAmerican journal of human genetics2010
Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.Human molecular genetics · 2014Pooled it
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- Recovering the pre-colonial population structure of Khoe-San descendant populations.bioRxiv : the preprint server for biology · 2025Article
- The Indian Ocean slave trade and colonial expansion resulted in strong sex-biased admixture in South Africa.American journal of human genetics · 2025Article
- Wide-scale geographical analysis of genetic ancestry in the South African Coloured population.BMC biology · 2025Article
- Persistence of Ancestral KhoeSan Mitochondrial Patterns in Contemporary South African Populations.Annals of human genetics · 2025Article
- 9,000 years of genetic continuity in southernmost Africa demonstrated at Oakhurst rockshelter.Nature ecology & evolution · 2024Article
- Race and ethnicity in the COVID-19 Critical Care Consortium: demographics, treatments, and outcomes, an international observational registry study.International journal for equity in health · 2023Observational
- Dutch founder SDHB exon 3 deletion in patients with pheochromocytoma-paraganglioma in South Africa.Endocrine connections · 2022Article
- Male-biased migration from East Africa introduced pastoralism into southern Africa.BMC biology · 2021Article
- Local Ancestry Adjusted Allelic Association Analysis Robustly Captures Tuberculosis Susceptibility Loci.Frontiers in genetics · 2021Article
- Patterns of African and Asian admixture in the Afrikaner population of South Africa.BMC biology · 2020Article
- Dating admixture events is unsolved problem in multi-way admixed populations.Briefings in bioinformatics · 2020Article
- C9orf72 repeat expansions in South Africans with amyotrophic lateral sclerosis.Journal of the neurological sciences · 2019Article
- Postcraniometric sex and ancestry estimation in South Africa: a validation study.International journal of legal medicine · 2019Article
- Using Whole Genome Sequencing in an African Subphenotype of Myasthenia Gravis to Generate a Pathogenetic Hypothesis.Frontiers in genetics · 2019Article
- Allelic resolution NGS HLA typing of Class I and Class II loci and haplotypes in Cape Town, South Africa.Human immunology · 2018Article
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9 authors.
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Abstract
The study of recently admixed populations provides unique tools for understanding recent population dynamics, socio-cultural factors associated with the founding of emerging populations, and the genetic basis of disease by means of admixture mapping. Historical records and recent autosomal data indicate that the South African Coloured population forms a unique highly admixed population, resulting from the encounter of different peoples from Africa, Europe, and Asia. However, little is known about the mode by which this admixed population was recently founded. Here we show, through detailed phylogeographic analyses of mitochondrial DNA and Y-chromosome variation in a large sample of South African Coloured individuals, that this population derives from at least five different parental populations (Khoisan, Bantus, Europeans, Indians, and Southeast Asians), who have differently contributed to the foundation of the South African Coloured. In addition, our analyses reveal extraordinarily unbalanced gender-specific contributions of the various population genetic components, the most striking being the massive maternal contribution of Khoisan peoples (more than 60%) and the almost negligible maternal contribution of Europeans with respect to their paternal counterparts. The overall picture of gender-biased admixture depicted in this study indicates that the modern South African Coloured population results mainly from the early encounter of European and African males with autochthonous Khoisan females of the Cape of Good Hope around 350 years ago.
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