ArticleNeuroscience2010
Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone.
Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Prenatal immune origins of brain aging differ by sex.Molecular psychiatry · 2025Article
- Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice.GeroScience · 2024Article
- The nitrone compound OKN-007 delays motor neuron loss and disease progression in the G93A mouse model of amyotrophic lateral sclerosis.Frontiers in neuroscience · 2024Article
- Preconditioning in hypoxic-ischemic neonate mice triggers NaCell death discovery · 2022Article
- Downregulation of transcriptional activity, increased inflammation, and damage in the placenta followingFrontiers in virology (Lausanne, Switzerland) · 2022Article
- Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice.GeroScience · 2022Article
- Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.Cell death discovery · 2021Article
- Neurobehavioural changes and morphological study of cerebellar purkinje cells in kaolin induced hydrocephalus.Anatomical science international · 2021Article
- A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis.Intensive care medicine experimental · 2020Article
- Short Term Usage of Omega-3 Polyunsaturated Fatty Acids Ameliorate Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in the Neonatal Rat Hippocampal Tissue.Frontiers in nutrition · 2020Article
- Genetic background modifies CNS-mediated sensorimotor decline in the AD-BXD mouse model of genetic diversity in Alzheimer's disease.Genes, brain, and behavior · 2019Article
- Negative geotaxis: An early age behavioral hallmark to VPA rat model of autism.Annals of neurosciences · 2019Article
- White matter damage after traumatic brain injury: A role for damage associated molecular patterns.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Erythropoietin Ameliorates Neonatal Hypoxia-Ischemia-Induced Neurobehavioral Deficits, Neuroinflammation, and Hippocampal Injury in the Juvenile Rat.International journal of molecular sciences · 2016Article
- Gene-environment interactions in severe intraventricular hemorrhage of preterm neonates.Pediatric research · 2014Review
- Interleukin-1 receptor blockade in perinatal brain injury.Frontiers in pediatrics · 2014Review
- Article
- Neonatal systemic exposure to lipopolysaccharide enhances susceptibility of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.Developmental neuroscience · 2013Article
- Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia.Developmental neuroscience · 2013Article
- A lifespan approach to neuroinflammatory and cognitive disorders: a critical role for glia.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Our previous study showed that perinatal exposure to interleukin-1beta (IL-1beta), an inflammatory cytokine, induces acute injury to developing white matter in the neonatal rat brain, and alpha-phenyl-n-tert-butyl-nitrone (PBN), a free radical scavenger and antioxidant, protects against IL-1beta-induced acute brain injury. The objective of the present study was to further examine whether perinatal exposure to IL-1beta resulted in persistent brain damage and neurological disabilities, and whether PBN offers lasting protection. Intracerebral injection of IL-1beta (1 microg/kg) was performed in postnatal day 5 (P5) Sprague-Dawley rat pups and PBN (100 mg/kg) or saline was administered intraperitoneally 5 min after IL-1beta injection. Perinatal IL-1beta exposure significantly affected neurobehavioral functions in juvenile rats. Although some neurobehavioral deficits such as performance in negative geotaxis, cliff avoidance, beam walking, and locomotion were spontaneously reversible, sustained deficits such as poor performance in the vibrissa-elicited forelimb-placing test, the pole test, the passive avoidance task, and the elevated plus-maze task were still observable at P21. Perinatal IL-1beta exposure resulted in persistent brain damage including enlargement of ventricles, loss of mature oligodendrocytes, impaired myelination as indicated by the decrease in myelin basic protein immunostaining, axonal and dendritic injury, and loss of hippocampal CA1 neurons and tyrosine hydroxylase positive neurons in the substantia nigra and ventral tegmental areas of the rat brain. Treatments with PBN provided lasting protection against the IL-1beta-induced brain injury and improved the associated neurological dysfunctions in juvenile rats, suggesting that prompt treatments for brain injury induced by perinatal infection/inflammation might have important long-term consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.