ArticleBrain research2010
High-fat intake induced by mu-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R- stimulation.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Homeostatic-related peptides injected into the rat nucleus accumbens alter palatable eating and impact the binge-like intake of a sweetened fat diet during simultaneous μ-opioid receptor stimulation.Frontiers in neuroscience · 2025Article
- Integration of Endogenous Opioid System Research in the Interprofessional Diagnosis and Treatment of Obesity and Eating Disorders.Advances in neurobiology · 2024Article
- Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.Advances in neurobiology · 2024Review
- Proopiomelanocortin projections to the nucleus accumbens modulate acquisition and maintenance of operant palatable pellet administration in mice.Physiology & behavior · 2023Article
- Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.Neuropeptides · 2022Article
- Structural basis of neuropeptide Y signaling through Y1 receptor.Nature communications · 2022Article
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Physiologic and Neural Controls of Eating.Gastroenterology clinics of North America · 2016Review
- Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.Biological psychiatry · 2015Article
- Manipulation of GABA in the ventral pallidum, but not the nucleus accumbens, induces intense, preferential, fat consumption in rats.Behavioural brain research · 2014Article
- Reversible hyperphagia and obesity in rats with gastric bypass by central MC3/4R blockade.Obesity (Silver Spring, Md.) · 2014Article
- Opioid hedonic hotspot in nucleus accumbens shell: mu, delta, and kappa maps for enhancement of sweetness "liking" and "wanting".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Opioid receptor mu 1 gene, fat intake and obesity in adolescence.Molecular psychiatry · 2014Article
- Decrease of Obesity by Allantoin via Imidazoline I 1 -Receptor Activation in High Fat Diet-Fed Mice.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Similarities in hypothalamic and mesocorticolimbic circuits regulating the overconsumption of food and alcohol.Physiology & behavior · 2011Review
- mu-Opioid receptor stimulation in the nucleus accumbens elevates fatty tastant intake by increasing palatability and suppressing satiety signals.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.Endocrinology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Nucleus accumbens mu-opioid receptor activation can strongly stimulate intake of high-fat food in satiated rats, and one of the mechanisms involves activation of lateral hypothalamic orexin neurons and orexin receptor-1 signaling in the mesolimbic dopamine system. Here, we tested the potential contribution of NPY/Y1R and alpha-MSH/MC3/4R-signaling to accumbens-induced high-fat feeding. Prior administration of the selective Y1R antagonist 1229U91 or the MC3/4R agonist MTII into the lateral ventricle (LV) dose-dependently decreased high-fat intake induced by nucleus accumbens injection of the mu-opioid receptor agonist DAMGO. Both drugs also decreased high-fat feeding induced by switching rats from regular chow to high-fat diet, but less efficiently than when DAMGO-induced. Administration of 1229U91 directly into the PVH also suppressed DAMGO-induced high-fat intake, but a higher dose was required. The results suggest that NPY/Y1R signaling in the PVH and other forebrain sites is necessary for accumbens DAMGO to elicit high-fat intake, and that forebrain MC3/4R signaling can suppress it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.