ArticleBMC evolutionary biology2010
The Mediterranean Sea as a barrier to gene flow: evidence from variation in and around the F7 and F12 genomic regions.
Article in BMC evolutionary biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease.European journal of human genetics : EJHG · 2017Article
- Determination of arylsulfatase A pseudodeficiency allele and haplotype frequency in the Tunisian population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- The burden of disease in Spain: results from the global burden of disease study 2010.BMC medicine · 2014Article
- North African influences and potential bias in case-control association studies in the Spanish population.PloS one · 2011Article
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6 authors.
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Abstract
backgroundThe Mediterranean has a long history of interactions among different peoples. In this study, we investigate the genetic relationships among thirteen population samples from the broader Mediterranean region together with three other groups from the Ivory Coast and Bolivia with a particular focus on the genetic structure between North Africa and South Europe. Analyses were carried out on a diverse set of neutral and functional polymorphisms located in and around the coagulation factor VII and XII genomic regions (F7 and F12).
resultsPrincipal component analysis revealed a significant clustering of the Mediterranean samples into North African and South European groups consistent with the results from the hierarchical AMOVA, which showed a low but significant differentiation between groups from the two shores. For the same range of geographic distances, populations from each side of the Mediterranean were found to differ genetically more than populations within the same side. To further investigate this differentiation, we carried out haplotype analyses, which provided partial evidence that sub-Saharan gene flow was higher towards North Africa than South Europe.
conclusionsAs there is no consensus between the two genomic regions regarding gene flow through the Sahara, it is hard to reach a solid conclusion about its role in the differentiation between the two Mediterranean shores and more data are necessary to reach a definite conclusion. However our data suggest that the Mediterranean Sea was at least partially a barrier to gene flow between the two shores.
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