ArticleInfectious agents and cancer2010
Multiple oncogenic viruses identified in Ocular surface squamous neoplasia in HIV-1 patients.
Article in Infectious agents and cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Epidemiology of ocular surface squamous neoplasia in Africa.Tropical medicine & international health : TM & IH · 2013Pooled it
- HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.British journal of cancer · 2013Pooled it
- The social and clinical profile of patients with ocular surface squamous cell carcinoma in Tanzania.BMC cancer · 2026Article
- The prevalence of human papillomavirus in ocular surface squamous neoplasia in HIV positive and negative patients in a South African population.Infection · 2024Article
- Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia.The ocular surface · 2024Article
- Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence.World journal of methodology · 2024Review
- Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients.Frontiers in oncology · 2022Article
- Role of oncogenic viruses in the development ocular surface squamous neoplasia.International ophthalmology · 2021Article
- Ocular surface squamous neoplasia at a tertiary eye facility, Southwestern Nigeria: a 10-year review.International ophthalmology · 2021Article
- Observational
- Observational
- Human Papilloma Virus Vaccination and Incidence of Ocular Surface Squamous Neoplasia.International ophthalmology clinics · 2017Review
- Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study.Tropical medicine & international health : TM & IH · 2016Article
- Human Papilloma Virus Infection Does Not Predict Response to Interferon Therapy in Ocular Surface Squamous Neoplasia.Ophthalmology · 2015Article
- Pathophysiology of ocular surface squamous neoplasia.Experimental eye research · 2014Review
- Cytokine production and antigen recognition by human mucosal homing conjunctival effector memory CD8+ T cells.Investigative ophthalmology & visual science · 2014Article
- Oncogenic viral prevalence in invasive vulvar cancer specimens from human immunodeficiency virus-positive and -negative women in Botswana.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2014Article
- Burkitt lymphoma research in East Africa: highlights from the 9(th) African organization for research and training in cancer conference held in Durban, South Africa in 2013.Infectious agents and cancer · 2014Article
- Oncogenic viruses associated with vulva cancer in HIV-1 patients in Botswana.Infectious agents and cancer · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOcular surface squamous neoplasia (OSSN) is a rare cancer that has increased in incidence with the HIV pandemic in Africa. The underlying cause of this cancer in HIV-infected patients from Botswana is not well defined.
resultsTissues were obtained from 28 OSSN and 8 pterygia patients. The tissues analyzed from OSSN patients were 83% positive for EBV, 75% were HPV positive, 70% were KSHV positive, 75% were HSV-1/2 positive, and 61% were CMV positive by PCR. Tissues from pterygium patients were 88% positive for EBV, 75% were HPV positive, 50% were KSHV positive, and 60% were CMV positive. None of the patients were JC or BK positive. In situ hybridization and immunohistochemistry analyses further identified HPV, EBV, and KSHV in a subset of the tissue samples.
conclusionWe identified the known oncogenic viruses HPV, KSHV, and EBV in OSSN and pterygia tissues. The presence of these tumor viruses in OSSN suggests that they may contribute to the development of this malignancy in the HIV population. Further studies are necessary to characterize the molecular mechanisms associated with viral antigens and their potential role in the development of OSSN.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.