ReviewCNS neuroscience & therapeutics2010
REVIEW: Apathy diagnosis, assessment, and treatment in Alzheimer's disease.
Review in CNS neuroscience & therapeutics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Apathy Associated with Alzheimer's Disease.Current Alzheimer research · 2024Pooled it
- Functional Living Skills in Patients with Major Neurocognitive Disorder Due to Degenerative or Non-Degenerative Conditions: Effectiveness of a Non-Immersive Virtual Reality Training.Sensors (Basel, Switzerland) · 2023Trial
- On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior.Molecular psychiatry · 2026Article
- Suppression of neuronal eEF2K alleviates cognitive deficits and apathy-like behavior in APP/PS1 AD model mice.Research square · 2026Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease.Neurobiology of aging · 2023Article
- A scoping review of neurodegenerative manifestations in explainable digital phenotyping.NPJ Parkinson's disease · 2023Article
- "He Just Doesn't Want to Get Out of the Chair and Do It": The Impact of Apathy in People with Dementia on Their Carers.International journal of environmental research and public health · 2021Article
- Subtle neuropsychiatric symptoms of glioblastoma multiforme misdiagnosed as depression.BMJ case reports · 2020Review
- Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer's Disease: Insights From Preclinical Models, Clinical Data, and Future Directions.Frontiers in aging neuroscience · 2020Review
- Effort Displayed During Appetitive Phase of Feeding Behavior Requires Infralimbic Cortex Activity and Histamine H1 Receptor Signaling.Frontiers in neuroscience · 2019Article
- Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.Molecular neurobiology · 2018Article
- Apathy in Alzheimer's disease.Current opinion in behavioral sciences · 2018Review
- Quantity of Movement as a Measure of Engagement for Dementia: The Influence of Motivational Disorders.American journal of Alzheimer's disease and other dementias · 2018Article
- A Feasibility Study with Image-Based Rendered Virtual Reality in Patients with Mild Cognitive Impairment and Dementia.PloS one · 2016Article
- The role of cognitive effort in subjective reward devaluation and risky decision-making.Scientific reports · 2015Article
- Relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma.Neuropsychiatric disease and treatment · 2015Article
- The translational study of apathy-an ecological approach.Frontiers in behavioral neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apathy is defined as a disorder of motivation. There is wide acknowledgement that apathy is an important behavioral syndrome in Alzheimer's disease and in various neuropsychiatric disorders. In light of recent research and the renewed interest in the correlates and impacts of apathy and in its treatments, it is important to develop criteria for apathy that will be widely accepted, have clear operational steps, and be easy to apply in clinical practice and in research settings. Meeting these needs was the focus for a task force that included members of the European Psychiatric Association, the European Alzheimer's Disease Consortium and experts from Europe, Australia and North America.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.