ArticleGenes, brain, and behavior2011
Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism.
Article in Genes, brain, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
99 citing papers in PubMed, 176 citations in OpenAlex.
- Prenatal stress and fluoxetine exposure in BTBR and B6 mice differentially affects autism-like behaviors in adult male and female offspring.Physiology & behavior · 2025Article
- Review
- The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice.GeroScience · 2025Article
- Role of Odor Novelty on Olfactory Issues in Autism Spectrum Disorder.Genes, brain, and behavior · 2024Review
- Animal Models of Autistic-like Behavior in Rodents: A Scoping Review and Call for a Comprehensive Scoring System.International journal of molecular sciences · 2024Article
- Amygdalar neurotransmission alterations in the BTBR mice model of idiopathic autism.Translational psychiatry · 2024Article
- Maturation of nucleus accumbens synaptic transmission signals a critical period for the rescue of social deficits in a mouse model of autism spectrum disorder.Molecular brain · 2023Article
- A comparison of stress reactivity between BTBR and C57BL/6J mice: an impact of early-life stress.Experimental brain research · 2023Article
- Oxidative stress and neuroimmune proteins in a mouse model of autism.Cell stress & chaperones · 2023Article
- What do mammals have to say about the neurobiology of acoustic communication?Molecular psychology : brain, behavior, and society · 2023Article
- Altered meningeal immunity contributing to the autism-like behavior of BTBRBrain, behavior, & immunity - health · 2022Article
- Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish.International journal of molecular sciences · 2022Review
- Modeling dopamine dysfunction in autism spectrum disorder: From invertebrates to vertebrates.Neuroscience and biobehavioral reviews · 2022Review
- Aerodynamics and motor control of ultrasonic vocalizations for social communication in mice and rats.BMC biology · 2022Article
- Effects of Congenital Blindness on Ultrasonic Vocalizations and Social Behaviors in the ZRDBA Mouse.Frontiers in behavioral neuroscience · 2022Article
- From Mating to Milk Access: A Review of Reproductive Vocal Communication in Mice.Frontiers in behavioral neuroscience · 2022Review
- Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups.Frontiers in behavioral neuroscience · 2022Article
- Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies.Neural regeneration research · 2021Review
- A comparison of the Avisoft (v.5.2) and MATLAB Mouse Song Analyzer (v.1.3) vocalization analysis systems in C57BL/6, Fmr1-FVB.129, NS-Pten-FVB, and 129 mice.Journal of neuroscience methods · 2020Article
- Genetic variants drive altered epigenetic regulation of endotoxin response in BTBR macrophages.Brain, behavior, and immunity · 2020Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
Abstract
Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.