ReviewActa physiologica (Oxford, England)2010
Disparity in regional and systemic circulatory capacities: do they affect the regulation of the circulation?
Review in Acta physiologica (Oxford, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- A Systematic Review of the Effects of Strength and Power Training on Performance in Cross-Country Skiers.Journal of sports science & medicine · 2022Pooled it
- Plasma Nucleotide Dynamics during Exercise and Recovery in Highly Trained Athletes and Recreationally Active Individuals.BioMed research international · 2018Trial
- Gender differences in the physiological responses and kinematic behaviour of elite sprint cross-country skiers.European journal of applied physiology · 2012Trial
- Applying ischemic preconditioning prior to endurance training improves hematological profile and performance in long-distance runners.European journal of applied physiology · 2026Article
- A critical assessment of sympathetic restraint in submaximal exercise: Implications for integrated cardiovascular circuit control in exercise.Experimental physiology · 2025Review
- Ageing and endothelium-mediated vascular dysfunction: the role of the NADPH oxidases.The Journal of physiology · 2023Article
- Sex Differences in Endurance Running.Sports medicine (Auckland, N.Z.) · 2022Review
- Do Sex Differences in Physiology Confer a Female Advantage in Ultra-Endurance Sport?Sports medicine (Auckland, N.Z.) · 2021Review
- Nutrition for Older Athletes: Focus on Sex-Differences.Nutrients · 2021Review
- Effects of impaired microvascular flow regulation on metabolism-perfusion matching and organ function.Microcirculation (New York, N.Y. : 1994) · 2021Review
- Cardiovascular Adaptations to Four Months Training in Middle-Aged Amateur Long-Distance Skiers.Diagnostics (Basel, Switzerland) · 2020Article
- A Single Dose of The Mango Leaf Extract ZynamiteNutrients · 2019Article
- Leg- vs arm-cycling repeated sprints with blood flow restriction and systemic hypoxia.European journal of applied physiology · 2019Article
- Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature.Physiological reports · 2019Article
- Cerebral blood flow changes during intermittent acute hypoxia in patients with heart failure.The Journal of international medical research · 2018Article
- Competition for blood flow distribution between respiratory and locomotor muscles: implications for muscle fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Noninvasive Assessment of the Effect of Position and Exercise on Pulse Arrival to Peripheral Vascular Beds in Healthy Volunteers.Frontiers in physiology · 2017Article
- Impact of age on the vasodilatory function of human skeletal muscle feed arteries.American journal of physiology. Heart and circulatory physiology · 2016Article
- The influence of sex, age, and race experience on pacing profiles during the 90 km Vasaloppet ski race.Open access journal of sports medicine · 2016Article
- Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
In this review we integrate ideas about regional and systemic circulatory capacities and the balance between skeletal muscle blood flow and cardiac output during heavy exercise in humans. In the first part of the review we discuss issues related to the pumping capacity of the heart and the vasodilator capacity of skeletal muscle. The issue is that skeletal muscle has a vast capacity to vasodilate during exercise [approximately 300 mL (100 g)(-1) min(-1)], but the pumping capacity of the human heart is limited to 20-25 L min(-1) in untrained subjects and approximately 35 L min(-1) in elite endurance athletes. This means that when more than 7-10 kg of muscle is active during heavy exercise, perfusion of the contracting muscles must be limited or mean arterial pressure will fall. In the second part of the review we emphasize that there is an interplay between sympathetic vasoconstriction and metabolic vasodilation that limits blood flow to contracting muscles to maintain mean arterial pressure. Vasoconstriction in larger vessels continues while constriction in smaller vessels is blunted permitting total muscle blood flow to be limited but distributed more optimally. This interplay between sympathetic constriction and metabolic dilation during heavy whole-body exercise is likely responsible for the very high levels of oxygen extraction seen in contracting skeletal muscle. It also explains why infusing vasodilators in the contracting muscles does not increase oxygen uptake in the muscle. Finally, when approximately 80% of cardiac output is directed towards contracting skeletal muscle modest vasoconstriction in the active muscles can evoke marked changes in arterial pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.