Evidence map›Paper›PMID 20345239›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2010

Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts.

Matthew J Memoli, Rachel J Hrabal, Arash Hassantoufighi, Maryna C Eichelberger, Jeffery K Taubenberger

Abstract readCase Reports
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011
    Trial
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Discovery of Novel Boron-ContainingMolecules (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Influenza A Virus Neuraminidase Inhibitors.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  13. miR-1975 serves as an indicator of clinical severity upon influenza infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Host susceptibility to severe influenza A virus infection.Critical care (London, England) · 2019
    Review
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew J MemoliViral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-3203, USA. memolim@niaid.nih.gov
Rachel J Hrabal
Arash Hassantoufighi
Maryna C Eichelberger
Jeffery K Taubenberger

Funding

H1N1 Influenza Clinical ResearchZIAAI001113 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI TAUBENBERGER, JEFFERY · 2009 to 2011
$3.9M
Intramural NIH HHS Z99 AI999999
6 · The paper itself

Abstract

Pandemic 2009 H1N1 virus isolates containing the neuraminidase inhibitor resistance mutation H275Y have been reported. We describe rapid selection for the H275Y resistance mutation during therapy in 2 immunocompromised individuals at 9 and 14 days of therapy, as well as the first described case of clinically significant resistance to peramivir.

Indexed as

Drug Resistance, ViralAcids, CarbocyclicAmino Acid SubstitutionAntiviral AgentsCyclopentanesFemaleGuanidinesHumansImmunocompromised HostInfluenza A Virus, H1N1 SubtypeInfluenza, HumanMaleMiddle AgedMolecular Sequence DataMutation, MissenseOseltamivirAcids, CarbocyclicAntiviral AgentsCyclopentanesGuanidinesOseltamivirperamivirRNA, Viral

Identifiers

PMID20345239
PMCPMC2946636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.