ArticleJournal of neurotrauma2010
Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury.
Article in Journal of neurotrauma, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms.Journal of neurotrauma · 2021Pooled it
- Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.Molecular neurobiology · 2019Review
- Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes.Frontiers in neurology · 2019Article
- Applying Systems Biology Methodology To Identify Genetic Factors Possibly Associated with Recovery after Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Genetic findings in sport-related concussions: potential for individualized medicine?Concussion (London, England) · 2017Review
- Primer in Genetics and Genomics, Article 2-Advancing Nursing Research With Genomic Approaches.Biological research for nursing · 2017Review
- Neuroglobin, a Factor Playing for Nerve Cell Survival.International journal of molecular sciences · 2016Review
- Neuroglobin overexpression improves sensorimotor outcomes in a mouse model of traumatic brain injury.Neuroscience letters · 2014Article
- Genetic determinants of neuroglobin transcription.Neurogenetics · 2014Article
- A blueprint for genomic nursing science.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2013Article
- The anti-apoptotic role of neuroglobin.Cells · 2012Article
- Neuroglobin-overexpression reduces traumatic brain lesion size in mice.BMC neuroscience · 2012Article
- Genetics and outcomes after traumatic brain injury (TBI): what do we know about pediatric TBI?Journal of pediatric rehabilitation medicine · 2012Review
- Transgenic overexpression of neuroglobin attenuates formation of smoke-inhalation-induced oxidative DNA damage, in vivo, in the mouse brain.Free radical biology & medicine · 2011Article
- Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates.Neuropathology and applied neurobiology · 2011Review
- Searching for the noninvasive biomarker holy grail: are urine proteomics the answer?Biological research for nursing · 2011Review
- An antiapoptotic neuroprotective role for neuroglobin.International journal of molecular sciences · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Neuroglobin has shown rich neuroprotective effects against cerebral hypoxia, and therefore has the potential to impact outcomes after traumatic brain injury (TBI). However, to date an association between genetic variation within the human neuroglobin (NGB) gene and recovery post-TBI has not been reported. The purpose of this study was to explore the relationship between NGB genotypes and outcomes (as assessed by the Glasgow Outcome Scale [GOS], the Disability Rating Scale [DRS], and the Neurobehavioral Rating Scale-Revised [NRS-R]) after severe TBI. Genotyping using TaqMan allele discrimination for two tagging single nucleotide polymorphisms (tSNPs) that represent the two haplotype blocks for NGB (rs3783988 and rs10133981) was completed on DNA obtained from 196 Caucasian patients recovering from severe TBI. Patients were dichotomized based on the presence of the variant allele for each tSNP. Chi-square and Fisher's exact tests were used to compare characteristics between groups. Multivariate linear regression was used to examine NGB tSNPs and recovery from severe TBI. Subjects with the TT genotype (wild-type) for rs3783988 were more likely to have better GOS and DRS scores at 3, 6, 12, and 24 months, while rs10133981 genotype was not significantly related to functional outcome. After controlling for age, gender, and Glasgow Coma Scale (GCS) score, those subjects with the rs3783988 TT genotype had more than a 2.65-times greater likelihood of better functional outcomes than individuals with genotypes harboring a variant allele. Data suggest that the haplotype block represented by rs3783988 in NGB appears to influence recovery after severe TBI. Represented within this haplotype block of NGB is the region that codes for the oxygen-binding portion of NGB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.