ArticleInternational orthopaedics2011
Microarray analysis identifies distinct gene expression profiles associated with histological subtype in human osteosarcoma.
Article in International orthopaedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.Frontiers in pharmacology · 2022Article
- Identification of potential key genes and functional role of CENPF in osteosarcoma using bioinformatics and experimental analysis.Experimental and therapeutic medicine · 2022Article
- Antitumor Effect of Sclerostin against Osteosarcoma.Cancers · 2021Article
- Antibody Conjugates for Sarcoma Therapy: How Far along Are We?Biomedicines · 2021Review
- Prostate Cancer Cell Extracellular Vesicles Increase Mineralisation of Bone Osteoblast Precursor Cells in an In Vitro Model.Biology · 2021Article
- Genetic Variant ofTechnology in cancer research & treatment · 2019Article
- Human Metaplastic Breast Carcinoma and Decorin.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2017Article
- Low expression of fibulin-1 correlates with unfavorable prognosis in gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Osteosarcoma tissues and cell lines from patients with differing serum alkaline phosphatase concentrations display minimal differences in gene expression patterns.Veterinary and comparative oncology · 2016Article
- Roles of bone morphogenetic protein signaling in osteosarcoma.International orthopaedics · 2014Review
- Regenerative therapy with mesenchymal stem cells at the site of malignant primary bone tumour resection: what are the risks of early or late local recurrence?International orthopaedics · 2014Article
- Augmented expression of urokinase plasminogen activator and extracellular matrix proteins associates with multiple myeloma progression.Clinical & experimental metastasis · 2014Article
- Spinal osteosarcoma.Clinical Medicine Insights. Oncology · 2013Review
- Pivotal regulatory network and genes in osteosarcoma.Archives of medical science : AMS · 2013Article
- The biology of small leucine-rich proteoglycans in bone pathophysiology.The Journal of biological chemistry · 2012Review
- Impact of close surgical margin on local recurrence and survival in osteosarcoma.International orthopaedics · 2012Article
- The genetics of osteosarcoma.Sarcoma · 2012Article
- Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model.Cancer biology & therapy · 2011Article
- Targeting the osteosarcoma cancer stem cell.Journal of orthopaedic surgery and research · 2010Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteosarcoma is the most common primary malignant bone tumour. Currently osteosarcoma classification is based on histological appearance. It was the aim of this study to use a more systematic approach to osteosarcoma classification based on gene expression analysis and to identify subtype specific differentially expressed genes. We analysed the global gene expression profiles of ten osteosarcoma samples using Affymetrix U133A arrays (five osteoblastic and five non-osteoblastic osteosarcoma patients). Differential gene expression analysis yielded 75 genes up-regulated and 97 genes down-regulated in osteoblastic versus non-osteoblastic osteosarcoma samples, respectively. These included genes involved in cell growth, chemotherapy resistance, angiogenesis, steroid- and neuropeptide hormone receptor activity, acute-phase response and serotonin receptor activity and members of the Wnt/ß-catenin pathway and many others. Furthermore, we validated the highly differential expression of six genes including angiopoietin 1, IGFBP3, ferredoxin 1, BMP, decorin, and fibulin 1 in osteoblastic osteosarcoma relative to non-osteoblastic osteosarcoma. Our results show the utility of gene expression analysis to study osteosarcoma subtypes, and we identified several genes that may play a role as potential therapeutic targets in the future.
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