ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2010
A quantitative study of the biotransformation of insulin-enhancing VO(2+) compounds.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 87 citations in OpenAlex.
- Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients.Metallomics : integrated biometal science · 2013Trial
- Mixed-Ligand Complex Formation in the Systems Containing the Potential Drug [VIVO(acac)2] with Blood and Cellular Bioligands. Implications on the Active Species Formed in the Organism.Inorganic chemistry · 2026Article
- In-Depth Mass Spectrometry Study of Vanadium(IV) Complexes with Model Peptides.Inorganic chemistry · 2024Article
- Multiple and Variable Binding of Pharmacologically Active Bis(maltolato)oxidovanadium(IV) to Lysozyme.Inorganic chemistry · 2022Article
- ESI-MS Study of the Interaction of Potential Oxidovanadium(IV) Drugs and Amavadin with Model Proteins.Inorganic chemistry · 2020Article
- Binding of V(IV)O²⁺ to the Fe binding sites of human serum transferrin. A theoretical study.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Vanadium. Its role for humans.Metal ions in life sciences · 2013Review
- Application of DFT methods to the study of the coordination environment of the VO2+ ion in V proteins.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2012Article
- Vanadyl bisacetylacetonate protects β cells from palmitate-induced cell death through the unfolded protein response pathway.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011Article
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4 authors at 3 institutions in 2 countries.
Funding
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Abstract
Potentiometric (pH titrations) and spectroscopic (electron paramagnetic resonance) methods have been used to determine the thermodynamic stability constants of the various VO(2+) complexes formed after the interaction of four insulin-enhancing vanadium compounds, [VO(6-mepic)(2)], cis-[VO(pic)(2)(H(2)O)], [VO(acac)(2)], and [VO(dhp)(2)], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic acid, picolinic acid, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, with high molecular mass [human serum apotransferrin (hTf) and human serum albumin (HSA)] and low molecular mass (lactate) components of blood serum. In particular, log beta values for the formation of (VO)hTf (13.0 +/- 0.5), (VO)(2)hTf (25.5 +/- 0.5), (VO)HSA (9.1 +/- 1.0), (VO) (2) (d) HSA (20.9 +/- 1.0), cis-VO(dhp)(2)(hTf) (25.5 +/- 0.6), cis-VO(dhp)(2)(HSA) (25.9 +/- 0.6), (VO)hTf(lact) (14.5 +/- 0.8), (VO)(2)hTf(lact)(2) (28.5 +/- 0.8), (VO)hTf(pic) (15.6 +/- 0.8), and (VO)(2)hTf(pic)(2) (30.4 +/- 0.8) were determined. The values of the stability constants were used to compare the calculated composition of ternary and quinary systems with that recently proposed by some of us through electron paramagnetic resonance and density functional theory methods (Sanna et al. in Inorg. Chem. 49:174-187, 2010) and to predict the distribution of VO(2+) ion in blood serum when one of the four insulin-enhancing vanadium compounds studied, [VO(carrier)(2)], is administered.
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