ArticlePloS one2010
Anopheles aquasalis Infected by Plasmodium vivax displays unique gene expression profiles when compared to other malaria vectors and plasmodia.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Unravelling the genome of the brackish water malaria vector Anopheles aquasalis.Scientific reports · 2023Article
- Amazonian Anopheles with low numbers of oocysts transmit Plasmodium vivax sporozoites during a blood meal.Scientific reports · 2022Article
- Host-Parasite Interactions: Regulation of Leishmania Infection in Sand Fly.Acta parasitologica · 2022Review
- Blood-stage antiplasmodial activity and oocyst formation-blockage of metallo copper-cinchonine complex.Frontiers in cellular and infection microbiology · 2022Article
- Microanatomy of the American Malaria Vector Anopheles aquasalis (Diptera: Culicidae: Anophelinae) Midgut: Ultrastructural and Histochemical Observations.Journal of medical entomology · 2019Article
- An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria.PLoS neglected tropical diseases · 2018Article
- The role of the peritrophic matrix and red blood cell concentration in Plasmodium vivax infection of Anopheles aquasalis.Parasites & vectors · 2018Article
- Promising approach to reducing Malaria transmission by ivermectin: Sporontocidal effect against Plasmodium vivax in the South American vectors Anopheles aquasalis and Anopheles darlingi.PLoS neglected tropical diseases · 2018Article
- Proteomics reveals major components of oogenesis in the reproductive tract of sugar-fed Anopheles aquasalis.Parasitology research · 2016Article
- Expression of active trypsin-like serine peptidases in the midgut of sugar-feeding female Anopheles aquasalis.Parasites & vectors · 2015Article
- An overview of malaria transmission from the perspective of Amazon Anopheles vectors.Memorias do Instituto Oswaldo Cruz · 2015Review
- The remarkable journey of adaptation of the Plasmodium falciparum malaria parasite to New World anopheline mosquitoes.Memorias do Instituto Oswaldo Cruz · 2014Review
- Transcriptome sequencing and developmental regulation of gene expression in Anopheles aquasalis.PLoS neglected tropical diseases · 2014Article
- Experimental Plasmodium vivax infection of key Anopheles species from the Brazilian Amazon.Malaria journal · 2013Article
- The genome of Anopheles darlingi, the main neotropical malaria vector.Nucleic acids research · 2013Article
- Susceptibility of Anopheles sinensis to Plasmodium vivax in malarial outbreak areas of central China.Parasites & vectors · 2013Article
- The roles of serpins in mosquito immunology and physiology.Journal of insect physiology · 2013Review
- Bacterial feeding, Leishmania infection and distinct infection routes induce differential defensin expression in Lutzomyia longipalpis.Parasites & vectors · 2013Article
- The role of reactive oxygen species in Anopheles aquasalis response to Plasmodium vivax infection.PloS one · 2013Article
- The JAK-STAT pathway controls Plasmodium vivax load in early stages of Anopheles aquasalis infection.PLoS neglected tropical diseases · 2011Article
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Malaria affects 300 million people worldwide every year and is endemic in 22 countries in the Americas where transmission occurs mainly in the Amazon Region. Most malaria cases in the Americas are caused by Plasmodium vivax, a parasite that is almost impossible to cultivate in vitro, and Anopheles aquasalis is an important malaria vector. Understanding the interactions between this vector and its parasite will provide important information for development of disease control strategies. To this end, we performed mRNA subtraction experiments using A. aquasalis 2 and 24 hours after feeding on blood and blood from malaria patients infected with P. vivax to identify changes in the mosquito vector gene induction that could be important during the initial steps of infection. A total of 2,138 clones of differentially expressed genes were sequenced and 496 high quality unique sequences were obtained. Annotation revealed 36% of sequences unrelated to genes in any database, suggesting that they were specific to A. aquasalis. A high number of sequences (59%) with no matches in any databases were found 24 h after infection. Genes related to embryogenesis were down-regulated in insects infected by P. vivax. Only a handful of genes related to immune responses were detected in our subtraction experiment. This apparent weak immune response of A. aquasalis to P. vivax infection could be related to the susceptibility of this vector to this important human malaria parasite. Analysis of some genes by real time PCR corroborated and expanded the subtraction results. Taken together, these data provide important new information about this poorly studied American malaria vector by revealing differences between the responses of A. aquasalis to P. vivax infection, in relation to better studied mosquito-Plasmodium pairs. These differences may be important for the development of malaria transmission-blocking strategies in the Americas.
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