ArticleInternational journal of dentistry2010
Gene polymorphisms in chronic periodontitis.
Article in International journal of dentistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature.International journal of implant dentistry · 2022Pooled it
- Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection.Clinical oral investigations · 2022Pooled it
- Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis.Disease markers · 2020Pooled it
- Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects.BioMed research international · 2019Pooled it
- Is there an association between IFN-γ +874A/T polymorphism and periodontitis susceptibility?: A meta-analysis.Medicine · 2017Pooled it
- Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis.Disease markers · 2017Pooled it
- Trial
- Analysis of new lactotransferrin gene variants in a case-control study related to periodontal disease in dog.Molecular biology reports · 2012Trial
- Innate Immunity Gene Variants Affect Periodontitis Susceptibility.Advances in experimental medicine and biology · 2026Article
- The role of genome-wide DNA methylation and polymorphisms in periodontitis etiology: A narrative review.Biomolecules & biomedicine · 2025Review
- The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
- Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis-A synthesis of recent findings.Periodontology 2000 · 2025Review
- Association BetweenInfection and drug resistance · 2025Review
- Unmasking the Silent Threat: Periodontal Health's Impact on COPD Severity and Hospitalization.Journal of personalized medicine · 2023Article
- Screening of interleukin 17F gene polymorphisms and eight subgingival pathogens in chronic periodontitis in Libyan patients.The Libyan journal of medicine · 2023Article
- Genetic Polymorphism and Gene Expression of β-Defensin-1 in Periodontitis Associated With Type 2 Diabetes Mellitus.Cureus · 2023Article
- Genomic Medicine in Canine Periodontal Disease: A Systematic Review.Animals : an open access journal from MDPI · 2023Review
- Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis.Frontiers in immunology · 2023Article
- Interferon-Gamma (IFNg) +874A/T Polymorphism Does Not Significantly Affect the Severity of Periodontitis.European journal of dentistry · 2022Article
- Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis.Biomedical reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare (R)-allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.