ArticleFrontiers in systems neuroscience2010
3D-Reconstructions and Virtual 4D-Visualization to Study Metamorphic Brain Development in the Sphinx Moth Manduca Sexta.
Article in Frontiers in systems neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Antennal sensilla and brain morphology during development in caddisflies.Cell and tissue research · 2026Article
- The sensory ecology of caterpillars.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory.Cureus · 2024Review
- Serotonergic Neurons in the Brain and Gnathal Ganglion of LarvalFrontiers in neuroanatomy · 2022Article
- Metamorphic development of the olfactory system in the red flour beetle (Tribolium castaneum, HERBST).BMC biology · 2021Article
- Article
- Visualization of insect metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Age estimation during the blow fly intra-puparial period: a qualitative and quantitative approach using micro-computed tomography.International journal of legal medicine · 2017Article
- Idiosyncratic development of sensory structures in brains of diapausing butterfly pupae: implications for information processing.Proceedings. Biological sciences · 2017Article
- Comparison of Navigation-Related Brain Regions in Migratory versus Non-Migratory Noctuid Moths.Frontiers in behavioral neuroscience · 2017Article
- Potential and limitations of X-Ray micro-computed tomography in arthropod neuroanatomy: a methodological and comparative survey.The Journal of comparative neurology · 2015Article
- Controlling feeding behavior by chemical or gene-directed targeting in the brain: what's so spatial about our methods?Frontiers in neuroscience · 2013Review
- Postembryonic lineages of the Drosophila brain: I. Development of the lineage-associated fiber tracts.Developmental biology · 2013Article
- Development of a scheme and tools to construct a standard moth brain for neural network simulations.Computational intelligence and neuroscience · 2012Article
- A subpopulation of mushroom body intrinsic neurons is generated by protocerebral neuroblasts in the tobacco hornworm moth, Manduca sexta (Sphingidae, Lepidoptera).Arthropod structure & development · 2011Article
- Molecular interaction of fenvalarate with actin.Bioinformation · 2011Article
- Technical and organizational considerations for the long-term maintenance and development of digital brain atlases and web-based databases.Frontiers in systems neuroscience · 2010Article
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4 authors.
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Abstract
DURING METAMORPHOSIS, THE TRANSITION FROM THE LARVA TO THE ADULT, THE INSECT BRAIN UNDERGOES CONSIDERABLE REMODELING: new neurons are integrated while larval neurons are remodeled or eliminated. One well acknowledged model to study metamorphic brain development is the sphinx moth Manduca sexta. To further understand mechanisms involved in the metamorphic transition of the brain we generated a 3D standard brain based on selected brain areas of adult females and 3D reconstructed the same areas during defined stages of pupal development. Selected brain areas include for example mushroom bodies, central complex, antennal- and optic lobes. With this approach we eventually want to quantify developmental changes in neuropilar architecture, but also quantify changes in the neuronal complement and monitor the development of selected neuronal populations. Furthermore, we used a modeling software (Cinema 4D) to create a virtual 4D brain, morphing through its developmental stages. Thus the didactical advantages of 3D visualization are expanded to better comprehend complex processes of neuropil formation and remodeling during development. To obtain datasets of the M. sexta brain areas, we stained whole brains with an antiserum against the synaptic vesicle protein synapsin. Such labeled brains were then scanned with a confocal laser scanning microscope and selected neuropils were reconstructed with the 3D software AMIRA 4.1.
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