ArticlePlant signaling & behavior2010
A functional connection between the clock component TOC1 and abscisic acid signaling pathways.
Article in Plant signaling & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Leaf Anatomical and Transcriptomic Coordination Underlies Drought Resilience in Psammophytes.International journal of molecular sciences · 2025Article
- Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.Plant communications · 2025Review
- A regulatory loop establishes the link between the circadian clock and abscisic acid signaling in rice.Plant physiology · 2023Article
- Limited water stress modulates expression of circadian clock genes in Brachypodium distachyon roots.Scientific reports · 2023Article
- Environment-mediated mutagenetic interference on genetic stabilization and circadian rhythm in plants.Cellular and molecular life sciences : CMLS · 2022Review
- Dynamic physiological and transcriptome changes reveal a potential relationship between the circadian clock and salt stress response in Ulmus pumila.Molecular genetics and genomics : MGG · 2022Article
- The key clock component ZEITLUPE (ZTL) negatively regulates ABA signaling by degradation of CHLH in Arabidopsis.Frontiers in plant science · 2022Article
- Transcriptomic response is more sensitive to water deficit in shoots than roots of Vitis riparia (Michx.).BMC plant biology · 2019Article
- Genome-Wide Identification of Splicing Quantitative Trait Loci (sQTLs) in Diverse Ecotypes ofFrontiers in plant science · 2019Article
- Article
- Comparative Analysis of the Chrysanthemum Leaf Transcript Profiling in Response to Salt Stress.PloS one · 2016Article
- Circadian clock-dependent gating in ABA signalling networks.Protoplasma · 2012Review
- Abscisic acid receptors.Plant physiology · 2010Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hormone abscisic acid (ABA) regulates the stress signals crucial for plant tolerance to adverse environmental conditions. The circadian clock also uses environmental cues for appropriate timing of plant physiology and metabolism. Despite previous studies showing the connections between ABA and clock signalling pathways, the molecular nodes underlying these connections remained unknown. In a recent study, we have shown that the essential clock component TOC1 (Timing of CAB expression 1) regulates the diurnal expression of the ABA-related gene ABAR/CHLH/GUN5 by direct binding to its promoter. Treatment with ABA specifically induces TOC1 at midday and this induction controls both the phase of TOC1 binding and the expression of ABAR. TOC1 induction by ABA is abolished in ABAR RNAi plants revealing a new feedback loop that reciprocally links ABAR and TOC1 expression. This regulation is essential for ABA function as TOC1 and ABAR overexpressing and mutant plants display altered ABA-mediated tolerance to drought conditions. Notably, TOC1 is also implicated in ABA-mediated inhibition of seed germination but in an opposite direction to that observed for dehydration responses. These opposing functions open interesting questions about the spatial and temporal networks connecting ABA and clock signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.