ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Pulmonary O2 uptake and leg blood flow kinetics during moderate exercise are slowed by hyperventilation-induced hypocapnic alkalosis.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- Voluntary hyperventilation-induced hypocapnia enhances wingate test performance without altering energy system contributions.BMC sports science, medicine & rehabilitation · 2025Article
- Development and validation of a nomogram to predict the unfavorable outcomes in elderly patients undergoing lumbar fusion surgery for degenerative disease.BMC surgery · 2024Article
- Baroreflex dynamics during the rest to exercise transient in acute normobaric hypoxia in humans.European journal of applied physiology · 2024Article
- Dynamics of cardiovascular and baroreflex readjustments during a light-to-moderate exercise transient in humans.European journal of applied physiology · 2022Article
- A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise.European journal of applied physiology · 2022Review
- Unexplained exertional intolerance associated with impaired systemic oxygen extraction.European journal of applied physiology · 2019Article
- Effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise.European journal of applied physiology · 2017Article
- Dynamics of the RR-interval versus blood pressure relationship at exercise onset in humans.European journal of applied physiology · 2017Article
- Effects of overground locomotor training on the ventilatory response to volitional treadmill walking in individuals with incomplete spinal cord injury: a pilot study.Spinal cord series and cases · 2017Article
- Effect of voluntary hypocapnic hyperventilation on the metabolic response during Wingate anaerobic test.European journal of applied physiology · 2015Article
- Effects of diaphragmatic contraction on lower limb venous return and central hemodynamic parameters contrasting healthy subjects versus heart failure patients at rest and during exercise.Physiological reports · 2014Article
- Exploring the vascular smooth muscle receptor landscape in vivo: ultrasound Doppler versus near-infrared spectroscopy assessments.American journal of physiology. Heart and circulatory physiology · 2014Article
- Experimental investigation of NIRS spatial sensitivity.Biomedical optics express · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of hyperventilation-induced hypocapnic alkalosis (Hypo) on the adjustment of pulmonary O2 uptake (VO2p) and leg femoral conduit artery ("bulk") blood flow (LBF) during moderate-intensity exercise (Mod) was examined in eight young male adults. Subjects completed four to six repetitions of alternate-leg knee-extension exercise during normal breathing [Con; end-tidal partial pressure of CO2 (PetCO2) approximately 40 mmHg] and sustained hyperventilation (Hypo; PetCO2 approximately 20 mmHg). Increases in work rate were made instantaneously from baseline (3 W) to Mod (80% estimated lactate threshold). VO2p was measured breath by breath by mass spectrometry and volume turbine, and LBF (calculated from mean femoral artery blood velocity and femoral artery diameter) was measured simultaneously by Doppler ultrasound. Concentration changes of deoxy (Delta[HHb])-, oxy (Delta[O2Hb])-, and total hemoglobin-myoglobin (Delta[HbTot]) of the vastus lateralis muscle were measured continuously by near-infrared spectroscopy (NIRS). The kinetics of VO2p, LBF, and Delta[HHb] were modeled using a monoexponential equation by nonlinear regression. The time constants for the phase 2 VO2p (Hypo, 49+/-26 s; Con, 28+/-8 s) and LBF (Hypo, 46+/-16 s; Con, 23+/-6 s) were greater (P<0.05) in Hypo compared with Con. However, the mean response time for the overall Delta[HHb] response was not different between conditions (Hypo, 23+/-5 s; Con, 24+/-3 s), whereas the Delta[HHb] amplitude was greater (P<0.05) in Hypo (8.05+/-7.47 a.u.) compared with Con (6.69+/-6.31 a.u.). Combined, these results suggest that hyperventilation-induced hypocapnic alkalosis is associated with slower convective (i.e., slowed femoral artery and microvascular blood flow) and diffusive (i.e., greater fractional O2 extraction for a given DeltaVO2p) O2 delivery, which may contribute to the hyperventilation-induced slowing of VO2p (and muscle O2 utilization) kinetics.
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