ArticleCerebral cortex (New York, N.Y. : 1991)2010
Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- GABAB-Dependent Negative Feedback Contributes to Earlier Epileptiform Discharge Termination Within Malformed Cortex.International journal of molecular sciences · 2026Article
- CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in focal cortical dysplasia.Acta neuropathologica communications · 2026Article
- Synaptic Dysregulation Drives Hyperexcitability in Pyramidal Neurons Surrounding Freeze-Induced Neocortical Malformations in Rats.International journal of molecular sciences · 2025Article
- Altered excitatory and inhibitory neocortical circuitry leads to increased convulsive severity after pentylenetetrazol injection in an animal model of schizencephaly, but not of microgyria.Epilepsia open · 2022Article
- Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice.Translational stroke research · 2021Article
- Circuit Mechanisms Underlying Epileptogenesis in a Mouse Model of Focal Cortical Malformation.Current biology : CB · 2021Article
- Why Malformations of Cortical Development Cause Epilepsy.Frontiers in neuroscience · 2019Article
- Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust.Neurobiology of disease · 2016Article
- Traumatic Brain Injury and Neuronal Functionality Changes in Sensory Cortex.Frontiers in systems neuroscience · 2016Review
- Inhibitory Circuits in Cortical Layer 5.Frontiers in neural circuits · 2016Review
- Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Microcircuits and their interactions in epilepsy: is the focus out of focus?Nature neuroscience · 2015Review
- Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.Neurobiology of disease · 2014Article
- Excitatory and inhibitory synaptic connectivity to layer V fast-spiking interneurons in the freeze lesion model of cortical microgyria.Journal of neurophysiology · 2014Article
- Endogenous subventricular zone neural progenitors contribute to the formation and hyperexcitability of experimental model of focal microgyria.Journal of molecular neuroscience : MN · 2014Article
- Early susceptibility for epileptiform activity in malformed cortex.Epilepsy research · 2014Article
- Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.Journal of neurophysiology · 2014Article
- Serotonin 1A receptors alter expression of movement representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Glutamate biosensor imaging reveals dysregulation of glutamatergic pathways in a model of developmental cortical malformation.Neurobiology of disease · 2013Article
- Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cortical dysplasias frequently underlie neurodevelopmental disorders and epilepsy. Rats with a neonatally induced cortical microgyrus [freeze-lesion (FL)], a model of human polymicrogyria, display epileptiform discharges in vitro. We probed excitatory and inhibitory connectivity onto neocortical pyramidal neurons in layers 2/3 and 5 of postnatal day 16-22 rats, approximately 1-2 mm lateral of the lesion, using laser scanning photostimulation (LSPS)/glutamate uncaging. Excitatory input from deep and supragranular layers to layer 5 pyramidal cells was greater in FL cortex, while no significant differences were seen in layer 2/3 cells. The increased input was due to a greater number of LSPS-evoked excitatory postsynaptic currents (EPSCs), without differences in amplitude or kinetics. Inhibitory input was increased in a region-specific manner in pyramidal cells in FL cortex, due to an increased inhibitory postsynaptic current (IPSC) amplitude. Connectivity within layer 5, parts of which are destroyed during lesioning, was more severely affected than connectivity in layer 2/3. Thus, we observed 2 distinct mechanisms of altered synaptic input: 1) increased EPSC frequency suggesting an increased number of excitatory synapses and 2) higher IPSC amplitude, suggesting an increased strength of inhibitory synapses. These increases in both excitatory and inhibitory connectivity may limit the extent of circuit hyperexcitability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.