ArticleNucleic acids research2010
Genome-wide computational identification of WG/GW Argonaute-binding proteins in Arabidopsis.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Haplotype-phased 'Ottawa 3' genome unravels differential reaction of apple rootstock roots to mixed viral infection.The Plant journal : for cell and molecular biology · 2026Article
- Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery.Microbiology spectrum · 2024Article
- A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis.Nature communications · 2024Article
- Mutations in the WG and GW motifs of the three RNA silencing suppressors of grapevine fanleaf virus alter their systemic suppression ability and affect virus infectivity.Frontiers in microbiology · 2024Article
- SPT6L, a newly discovered ancestral component of the plant RNA-directed DNA methylation pathway.Frontiers in plant science · 2024Article
- Review
- Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants.eLife · 2021Article
- The potyviral silencing suppressor HCPro recruits and employs host ARGONAUTE1 in pro-viral functions.PLoS pathogens · 2020Article
- RNA-induced initiation of transcriptional silencing (RITS) complex structure and function.RNA biology · 2019Review
- RNA polymerase II-independent recruitment of SPT6L at transcription start sites in Arabidopsis.Nucleic acids research · 2019Article
- Biochemical and genetic functional dissection of the P38 viral suppressor of RNA silencing.RNA (New York, N.Y.) · 2017Article
- The Argonaute-binding platform of NRPE1 evolves through modulation of intrinsically disordered repeats.The New phytologist · 2016Article
- DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape.The Plant cell · 2016Article
- Comparison of Surface Proteomes of Adherence Variants of Listeria Monocytogenes Using LC-MS/MS for Identification of Potential Surface Adhesins.Pathogens (Basel, Switzerland) · 2016Article
- Functional dissection of a plant Argonaute.Nucleic acids research · 2016Article
- Ancient Origin and Recent Innovations of RNA Polymerase IV and V.Molecular biology and evolution · 2015Article
- Extensive Transcriptome Changes During Natural Onset and Release of Vegetative Bud Dormancy in Populus.Frontiers in plant science · 2015Article
- Early origin and adaptive evolution of the GW182 protein family, the key component of RNA silencing in animals.RNA biology · 2015Article
- Composition and function of P bodies in Arabidopsis thaliana.Frontiers in plant science · 2014Review
- Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domains in Arabidopsis proteins NRPE1 and SPT5-like, composed almost exclusively of repeated motifs in which only WG or GW sequences and an overall amino-acid preference are conserved, have been experimentally shown to bind multiple molecules of Argonaute (AGO) protein(s). Domain swapping between the WG/GW domains of NRPE1 and the human protein GW182 showed a conserved function. As classical sequence alignment methods are poorly-adapted to detect such weakly-conserved motifs, we have developed a tool to carry out a systematic analysis to identify genes potentially encoding AGO-binding GW/WG proteins. Here, we describe exhaustive analysis of the Arabidopsis genome for all regions potentially encoding proteins bearing WG/GW motifs and consider the possible role of some of them in AGO-dependent mechanisms. We identified 20 different candidate WG/GW genes, encoding proteins in which the predicted domains range from 92aa to 654aa. These mostly correspond to a limited number of families: RNA-binding proteins, transcription factors, glycine-rich proteins, translation initiation factors and known silencing-associated proteins such as SDE3. Recent studies have argued that the interaction between WG/GW-rich domains and AGO proteins is evolutionarily conserved. Here, we demonstrate by an in silico domain-swapping simulation between plant and mammalian WG/GW proteins that the biased amino-acid composition of the AGO-binding sites is conserved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.