ArticleBiophysical journal2010
Theoretical predictions of the effects of force transmission by desmin on intersarcomere dynamics.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023Review
- Desmin Knock-Out Cardiomyopathy: A Heart on the Verge of Metabolic Crisis.International journal of molecular sciences · 2022Article
- Repeated and Interrupted Resistance Exercise Induces the Desensitization and Re-Sensitization of mTOR-Related Signaling in Human Skeletal Muscle Fibers.International journal of molecular sciences · 2022Article
- What does desmin do: A bibliometric assessment of the functions of the muscle intermediate filament.Experimental biology and medicine (Maywood, N.J.) · 2022Article
- Review
- Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using theInternational journal of molecular sciences · 2020Article
- Biomechanical response of skeletal muscle to eccentric contractions.Journal of sport and health science · 2018Review
- Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network.Journal of cell science · 2015Article
- Role of the cytoskeleton in muscle transcriptional responses to altered use.Physiological genomics · 2013Article
- Pathways of Ca²⁺ entry and cytoskeletal damage following eccentric contractions in mouse skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Skeletal muscle fibrosis develops in response to desmin deletion.American journal of physiology. Cell physiology · 2012Article
- Eccentric contraction-induced injury to type I, IIa, and IIa/IIx muscle fibers of elderly adults.Age (Dordrecht, Netherlands) · 2012Article
- Influences of desmin and keratin 19 on passive biomechanical properties of mouse skeletal muscle.Journal of biomedicine & biotechnology · 2012Article
- The desmin coil 1B mutation K190A impairs nebulin Z-disc assembly and destabilizes actin thin filaments.Journal of cell science · 2011Article
- Non-uniform distribution of strain during stretch of relaxed skeletal muscle fibers from rat soleus muscle.Journal of muscle research and cell motility · 2011Article
- Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.American journal of physiology. Cell physiology · 2011Article
- Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers.The Journal of cell biology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Desmin is an intermediate filament protein in skeletal muscle that forms a meshlike network around Z-disks. A model of a muscle fiber was developed to investigate the mechanical role of desmin. A two-dimensional mesh of viscoelastic sarcomere elements was connected laterally by elastic elements representing desmin. The equations of motion for each sarcomere boundary were evaluated at quasiequilibrium to determine sarcomere stresses and strains. Simulations of passive stretch and fixed-end contractions yielded values for sarcomere misalignment and stress in wild-type and desmin null fibers. Passive sarcomere misalignment increased nonlinearly with fiber strain in both wild-type and desmin null simulations and was significantly larger without desmin. During fixed-end contraction, desmin null simulations also demonstrated greater sarcomere misalignment and reduced stress production compared with wild-type. In simulations with only a fraction of wild-type desmin present, fixed-end stress increased as a function of desmin concentration and this relationship was influenced by the cellular location of the desmin filaments. This model suggests that desmin stabilizes Z-disks and enables greater stress production by providing a mechanical tether between adjacent myofibrils and to the extracellular matrix and that the significance of the tether is a function of its location within the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.