ArticleBiophysical journal2010
A biophysically based mathematical model for the kinetics of mitochondrial Na+-Ca2+ antiporter.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- Influence of T-Bar on Calcium Concentration Impacting Release Probability.Frontiers in computational neuroscience · 2022Article
- Calcium phosphate precipitation inhibits mitochondrial energy metabolism.PLoS computational biology · 2019Article
- Different approaches to modeling analysis of mitochondrial swelling.Mitochondrion · 2018Review
- Interplay Between Intracellular Ca(2+) Oscillations and Ca(2+)-stimulated Mitochondrial Metabolism.Scientific reports · 2016Article
- Mitochondrial calcium uptake.Proceedings of the National Academy of Sciences of the United States of America · 2013Review
- Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release.Journal of bioenergetics and biomembranes · 2013Article
- Modeling the calcium sequestration system in isolated guinea pig cardiac mitochondria.Journal of bioenergetics and biomembranes · 2013Article
- Sensitivity of rabbit ventricular action potential and Ca²⁺ dynamics to small variations in membrane currents and ion diffusion coefficients.BioMed research international · 2013Article
- Sodium accumulation in SERCA knockout-induced heart failure.Biophysical journal · 2012Article
- Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries.Frontiers in physiology · 2012Article
- Characterization of Mg2+ inhibition of mitochondrial Ca2+ uptake by a mechanistic model of mitochondrial Ca2+ uniporter.Biophysical journal · 2011Article
- Detailed kinetics and regulation of mammalian 2-oxoglutarate dehydrogenase.BMC biochemistry · 2011Article
- Article
- Simulation of cellular biochemical system kinetics.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sodium-calcium antiporter is the primary efflux pathway for Ca(2+) in respiring mitochondria, and hence plays an important role in mitochondrial Ca(2+) homeostasis. Although experimental data on the kinetics of Na(+)-Ca(2+) antiporter are available, the structure and composition of its functional unit and kinetic mechanisms associated with the Na(+)-Ca(2+) exchange (including the stoichiometry) remains unclear. To gain a quantitative understanding of mitochondrial Ca(2+) homeostasis, a biophysical model of Na(+)-Ca(2+) antiporter is introduced that is thermodynamically balanced and satisfactorily describes a number of independent data sets under a variety of experimental conditions. The model is based on a multistate catalytic binding mechanism for carrier-mediated facilitated transport and Eyring's free energy barrier theory for interconversion and electrodiffusion. The model predicts the activating effect of membrane potential on the antiporter function for a 3Na(+):1Ca(2+) electrogenic exchange as well as the inhibitory effects of both high and low pH seen experimentally. The model is useful for further development of mechanistic integrated models of mitochondrial Ca(2+) handling and bioenergetics to understand the mechanisms by which Ca(2+) plays a role in mitochondrial signaling pathways and energy metabolism.
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