ReviewDrug and alcohol dependence2010
Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.
Review in Drug and alcohol dependence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms.Cancers · 2025Review
- An Investigation into Proteomic Constituents of Cerebrospinal Fluid in Patients with Chronic Peripheral Neuropathic Pain Medicated with Opioids- a Pilot Study.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Opiates and Plasticity in the Ventral Tegmental Area.ACS chemical neuroscience · 2017Review
- Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis.Journal of visualized experiments : JoVE · 2015Article
- In vivo opioid receptor heteromerization: where do we stand?British journal of pharmacology · 2015Review
- Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking.British journal of pharmacology · 2015Article
- Imaging endogenous opioid peptide release with [11C]carfentanil and [3H]diprenorphine: influence of agonist-induced internalization.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- Association of OPRD1 polymorphisms with heroin dependence in a large case-control series.Addiction biology · 2014Article
- An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.ACS chemical biology · 2013Article
- Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.Pharmacological reviews · 2013Review
- The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.The Journal of biological chemistry · 2012Article
- In vivo visualization of delta opioid receptors upon physiological activation uncovers a distinct internalization profile.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacology.Drug and alcohol dependence · 2012Review
- Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons.British journal of pharmacology · 2012Review
- Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use.EMBO molecular medicine · 2011Article
- Article
- Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.European journal of medicinal chemistry · 2011Article
- Mix and match: heterodimers and opioid tolerance.Neuron · 2011Article
- Introduction to the College on Problems of Drug Dependence special issue: contemporary advances in opioid neuropharmacology.Drug and alcohol dependence · 2010Article
- Overview and historical perspective of four papers presented on research related to the endogenous opioid system.Drug and alcohol dependence · 2010Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Opioid neuropeptide receptors mediate diverse physiological functions and are important targets for both therapeutic and abused drugs. Opioid receptors are highly regulated in intact cells, and there is reason to believe that this regulation controls the clinical effects of opioid drugs. The present review will discuss some of this evidence, focusing specifically on the regulation of opioid receptors by endocytic membrane trafficking mechanisms. First, some basic principles of regulated endocytosis will be reviewed, and the principle of 'molecular sorting' as a means to determine the functional consequences of endocytosis will be introduced, Most of this information has been derived from studies of simplified cell models. Second, present knowledge about the operation of these mechanisms in physiologically relevant CNS neurons will be discussed, focusing on studies of neurons cultured from rodent brain. Third, recent insight into the effects of endocytic trafficking on opioid regulation in vivo will be considered, focusing on results from studies of transgenic mouse models. Much remains to be learned at these pre-clinical levels, and effects of endocytosis on opioid actions in humans remain completely unexplored. Two particular insights, which have emerged from pre-clinical studies, will be proposed for translational consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.