ArticleCancer2010
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.
Article in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Association ofBioscience reports · 2019Pooled it
- Investigation of miR-21-5p Key Target Genes and Pathways in Head and Neck Squamous Cell Carcinoma Based on TCGA Database and Bioinformatics Analysis.Technology in cancer research & treatmentPooled it
- Assessment of genetic susceptibility in patients with oral squamous cell carcinoma: a systematic review and meta-analysis.Communications medicine · 2026Article
- An alcohol dehydrogenase 7 gene polymorphism associates with both acute and chronic pain in sickle cell disease.Pharmacogenomics · 2023Article
- Impact of Alcohol Dehydrogenase 7 Polymorphism and Alcohol Consumption on Risk of Head and Neck Squamous Cell Carcinoma: A Korean Case-Control Study.Journal of clinical medicine · 2023Article
- Inverse molecular docking reveals a novel function of thymol: Inhibition of fat deposition induced by high-dose glucose inFood science & nutrition · 2021Article
- A Genome-Wide Association Study Identifies Two Novel Susceptible Regions for Squamous Cell Carcinoma of the Head and Neck.Cancer research · 2020Article
- Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis.Alcoholism, clinical and experimental research · 2015Article
- An enhancer-blocking element regulates the cell-specific expression of alcohol dehydrogenase 7.Gene · 2014Article
- Single-nucleotide polymorphisms interact to affect ADH7 transcription.Alcoholism, clinical and experimental research · 2014Article
- Single nucleotide polymorphisms of mucosa-associated lymphoid tissue 1 in oral carcinoma cells and gingival fibroblasts.Odontology · 2013Article
- Retinoid metabolism is altered in human and mouse cicatricial alopecia.The Journal of investigative dermatology · 2013Article
- Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.Carcinogenesis · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
methodsMultivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False-positive report probabilities (FPRPs) also were calculated for significant findings.
resultsThe ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13-0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59-0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP.
conclusionsThe current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.
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