ArticleHuman brain mapping2011
Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals.
Article in Human brain mapping, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- A coordinate-based ALE functional MRI meta-analysis of brain activation during verbal fluency tasks in healthy control subjects.BMC neuroscience · 2014Pooled it
- Interpretable machine learning to evaluate relationships between DAO/DAOA (pLG72) protein data and features in clinical assessments, functional outcome, and cognitive function in schizophrenia patients.Schizophrenia (Heidelberg, Germany) · 2025Article
- Correction to "Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals".Human brain mapping · 2024Article
- Reorganization of motor network in patients with Parkinson's disease after deep brain stimulation.CNS neuroscience & therapeutics · 2024Article
- Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.International journal of molecular sciences · 2024Article
- Effect of DAOA genetic variation on white matter alteration in corpus callosum in patients with first-episode schizophrenia.Brain imaging and behavior · 2021Article
- Genetic EffectsNeuropsychiatric disease and treatment · 2020Article
- G72 primate-specific gene: a still enigmatic element in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2016Review
- A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13.Genes, brain, and behavior · 2015Article
- A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.Human brain mapping · 2015Article
- A preliminary fMRI study of a novel self-paced written fluency task: observation of left-hemispheric activation, and increased frontal activation in late vs. early task phases.Frontiers in human neuroscience · 2015Article
- Increased neural activity during overt and continuous semantic verbal fluency in major depression: mainly a failure to deactivate.European archives of psychiatry and clinical neuroscience · 2014Article
- Expression of the G72/G30 gene in transgenic mice induces behavioral changes.Molecular psychiatry · 2014Article
- Dissociable neural systems underwrite logical reasoning in the context of induced emotions with positive and negative valence.Frontiers in human neuroscience · 2014Article
- Interaction between effects of genes coding for dopamine and glutamate transmission on striatal and parahippocampal function.Human brain mapping · 2013Article
- Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia.Age (Dordrecht, Netherlands) · 2013Article
- Genotypic association of the DAOA gene with resting-state brain activity in major depression.Molecular neurobiology · 2012Article
- D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians.European archives of psychiatry and clinical neuroscience · 2012Article
- Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.Human brain mapping · 2012Article
- Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The D-amino acid oxidase activator gene (G72) has been found associated with several psychiatric disorders such as schizophrenia, major depression, and bipolar disorder. Impaired performance in verbal fluency tasks is an often replicated finding in the mentioned disorders. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and lateral temporal areas and could possibly constitute an endophenotype. Therefore, it is of interest whether genes associated with the disorders, such as G72, modulate verbal fluency performance and its neural correlates. Ninety-six healthy individuals performed a semantic verbal fluency task while brain activation was measured with functional MRI. All subjects were genotyped for two single nucleotide polymorphisms (SNP) in the G72 gene, M23 (rs3918342) and M24 (rs1421292), that have previously shown association with the above-mentioned disorders. The effect of genotype on brain activation was assessed with fMRI during a semantic verbal fluency task. Although there were no differences in performance, brain activation in the right middle temporal gyrus (BA 39) and the right precuneus (BA 7) was positively correlated with the number of M24 risk alleles in the G72 gene. G72 genotype does modulate brain activation during language production on a semantic level in key language areas. These findings are in line with structural and functional imaging studies in schizophrenia, which showed alterations in the right middle temporal gyrus.
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