ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2010
Impact of pretreatment hematologic profile on survival of colorectal cancer patients.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Thrombocytosis predicts poor prognosis of Asian patients with colorectal cancer: A systematic review and meta-analysis.Medicine · 2022Pooled it
- Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis.Oncotarget · 2016Pooled it
- Impact of preoperative anemia on outcomes in patients undergoing curative resection for gastric cancer: a single-institution retrospective analysis of 2163 Chinese patients.Cancer medicine · 2018Trial
- Association between the Khorana risk score and all-cause mortality in Japanese patients with gastric and colorectal cancer: A retrospective cohort study.World journal of gastrointestinal oncology · 2023Article
- Effect of peri-operative blood transfusions on long-term prognosis of patients with colorectal cancer.Blood transfusion = Trasfusione del sangue · 2022Article
- Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?Current oncology (Toronto, Ont.) · 2021Article
- The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis.Oncotarget · 2017Article
- Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis.Annals of intensive care · 2017Article
- Clinical Predictors of Early Mortality in Colorectal Cancer Patients Undergoing Chemotherapy: Results From a Global Prospective Cohort Study.JNCI cancer spectrum · 2017Article
- Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study.International journal of colorectal disease · 2017Article
- Peripheral Leukocytosis Is Inversely Correlated with Intratumoral CD8+ T-Cell Infiltration and Associated with Worse Outcome after Chemoradiotherapy in Anal Cancer.Frontiers in immunology · 2017Article
- A Validated Risk Score for Venous Thromboembolism Is Predictive of Cancer Progression and Mortality.The oncologist · 2016Article
- Preoperative thrombocytosis predicts prognosis in stage II colorectal cancer patients.Annals of surgical treatment and research · 2016Article
- Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor.Pathology oncology research : POR · 2015Article
- T4 stage and preoperative anemia as prognostic factors for the patients with colon cancer treated with adjuvant FOLFOX chemotherapy.World journal of surgical oncology · 2015Article
- Colorectal cancer and hypercoagulability.Surgery today · 2014Review
- Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients.World journal of gastroenterology · 2014Article
- Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.Intensive care medicine · 2014Article
- Direct and indirect costs of co-infection in the wild: Linking gastrointestinal parasite communities, host hematology, and immune function.International journal for parasitology. Parasites and wildlife · 2012Article
- Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors.BMC cancer · 2012Article
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8 authors.
Funding
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Abstract
Pretreatment hematologic abnormalities have been reported to have prognostic value in patients with solid tumors. The aim of our study was to determine the prevalence of abnormalities in the hematologic profile in patients with colorectal cancer before treatment and to evaluate if such a profile could be used for prognostic evaluations. We identified all patients in Cancer Center of Sun Yat-Sen University who were diagnosed as colorectal cancers between May 2005 and August 2009. All subjects were investigated regarding levels of white blood cells, platelets, and hemoglobin concentration. Survival was compared by using the log-rank test on the Kaplan-Meier life table. Multivariate Cox regression analysis was used to evaluate if the pretreatment hematologic profile was independent prognostic factor. We identified 363 patients with colorectal cancer and 315 patients with benign diseases for the final analysis. The percentages of leukocytosis, anemia, and thrombocytosis were significantly higher in colorectal cancer patients than in patients with benign diseases. Univariate analysis showed that advanced tumor stages, leukocytosis, anemia, thrombocytosis, and low histological grade were all significantly associated with shorter survival. The multivariate Cox analysis revealed that low histological grade, tumor stage, pretreatment anemia, and thrombocytosis remained independent prognostic variables for survival. The cumulative effect of anemia and thrombocytosis yielded shorter survival. Anemia and thrombocytosis can be considered as useful prognostic markers in patients with colorectal cancer.
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