ReviewCellular and molecular life sciences : CMLS2010
Contrasting models for kinetochore microtubule attachment in mammalian cells.
Review in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- <italic>Zea mays</italic> Meiotic Spindle Ultrastructure Reveals Kinetochore-Microtubule Interface and Embedded Membrane Components.Cytogenetic and genome research · 2025Article
- Aurora B Tension Sensing Mechanisms in the Kinetochore Ensure Accurate Chromosome Segregation.International journal of molecular sciences · 2021Review
- Dynamics of kinetochore structure and its regulations during mitotic progression.Cellular and molecular life sciences : CMLS · 2020Review
- Complete microtubule-kinetochore occupancy favours the segregation of merotelic attachments.Nature communications · 2018Article
- Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores.The Journal of cell biology · 2013Article
- Review
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- SUMOylation in control of accurate chromosome segregation during mitosis.Current protein & peptide science · 2012Review
- Maturation of the kinetochore-microtubule interface and the meaning of metaphase.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Review
- Mitotic spindle form and function.Genetics · 2012Article
- Assembling pieces of the centromere epigenetics puzzle.Epigenetics · 2012Review
- Visualizing kinetochore architecture.Current opinion in structural biology · 2011Review
- Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint.Molecular and cellular biology · 2011Review
- Centromeres: unique chromatin structures that drive chromosome segregation.Nature reviews. Molecular cell biology · 2011Review
- The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment.The Journal of cell biology · 2011Article
- Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.Current biology : CB · 2011Article
- Kinetochore assembly: if you build it, they will come.Current opinion in cell biology · 2011Review
- Kinetochores' gripping feat: conformational wave or biased diffusion?Trends in cell biology · 2011Review
- Molecular structures and interactions in the yeast kinetochore.Cold Spring Harbor symposia on quantitative biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Kinetochore function is mediated through its interaction with microtubule plus ends embedded in the kinetochore outer plate. Here, we compare and evaluate current models for kinetochore microtubule attachment, beginning with a brief review of the molecular, biochemical, cellular, and structural studies upon which these models are based. The majority of these studies strongly support a model in which the kinetochore outer plate is a network of fibers that form multiple weak attachments to each microtubule, chiefly through the Ndc80 complex. Multiple weak attachments enable kinetochores to remain attached to microtubule plus ends that are continually growing and shrinking. It is unlikely that rings or "kinetochore fibrils" have a significant role in kinetochore microtubule attachment, but such entities could have a role in stabilizing attachment, modifying microtubule dynamics, and harnessing the energy released from microtubule disassembly. It is currently unclear whether kinetochores control and coordinate the dynamics of individual kinetochore microtubules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.