ArticleHistochemistry and cell biology2010
Dermal papilla cells induce keratinocyte tubulogenesis in culture.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Generation of Hair Follicle Germs In Vitro Using Human Postnatal Skin Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Methionine Modulates the Growth and Development of Heat-Stressed Dermal Papilla Cells via the Wnt/β-Catenin Signaling Pathway.International journal of molecular sciences · 2025Article
- Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics.Scientific reports · 2023Article
- Article
- Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls.Bioengineering & translational medicine · 2022Review
- Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration.Materials today. Bio · 2021Review
- Advanced Medical Therapies in the Management of Non-Scarring Alopecia: Areata and Androgenic Alopecia.International journal of molecular sciences · 2020Review
- Regeneration of skin appendages and nerves: current status and further challenges.Journal of translational medicine · 2020Review
- Review
- Multimodal label-free imaging of living dermal equivalents including dermal papilla cells.Stem cell research & therapy · 2018Article
- Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.Stem cells international · 2017Article
- Skin-derived stem cells as a source of primordial germ cell- and oocyte-like cells.Cell death & disease · 2016Review
- Epidermal stem cells and skin tissue engineering in hair follicle regeneration.World journal of stem cells · 2015Review
- Article
- Article
- Histochemistry and cell biology: the annual review 2010.Histochemistry and cell biology · 2011Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of dermal papilla (DP) cells to induce hair growth was reported in many studies. However, early stages of hair follicle development and signals that govern this process are poorly understood. Therefore, an in vitro model may be a convenient system to study epithelial-mesenchymal interactions and early stages of epidermal morphogenesis, especially in humans. To investigate the role of DP cells in epidermal morphogenesis we modified the method of isolation of DP cells from hair follicle of human scalp and developed the three-dimensional model of epidermal morphogenesis. Isolated DP cells were able to differentiate in adipogenic and osteogenic directions and retained activity of alkaline phosphatase (AP) for seven passages in culture. DP cells were able to induce tubule-like structures in three-dimensional model in vitro and to reorganize collagen matrix. Prolonged cultivation of DP cells has been a big problem because of the loss of hair follicle-inducing ability and growth activity after several passages. To solve this problem we immortalized DP cells by the transfection of the human telomerase reverse transcriptase cDNA (hTERT). Immortalized DP-hTERT cells retained AP activity and demonstrated low ability to osteogenic differentiation. The conditioned medium collected from actively proliferated cells as well as DP-hTERT cells themselves were capable to induce tubulogenesis after prolonged keratinocyte cultivation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.