ArticleIndian journal of pharmacology2009
Is cytochrome modulation the new frontier for decreasing the risk of cataract?
Article in Indian journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Role of Cytochrome Modulators in Altering the Occurrence of Cataract in Rats.Journal of clinical and diagnostic research : JCDR · 2015Article
- Effect of rifampicin and erythromycin on the initiation of galactose induced cataract in rats.Journal of pharmacology & pharmacotherapeutics · 2012Article
- Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses.Human genomics · 2012Article
- Is cytochrome modulation the new frontier for decreasing the risk of cataract?Indian journal of pharmacology · 2009Article
- Cytochrome modulation decreases the risk of cataract: Is the basic hypothesis flawless?Indian journal of pharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. MATERIALS AND
methodsMacroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. RESULTS AND
conclusionA delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.
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Registered trials
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