Evidence map›Paper›PMID 20335655›Full record

ArticleThe Journal of clinical investigation2010

Epithelial-mesenchymal transitions and hepatocarcinogenesis.

Janice Jou, Anna Mae Diehl

Abstract readComment
In one paragraph

Article in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Janice JouDivision of Gastroenterology, Duke University, Durham, North Carolina 27710, USA.
Anna Mae Diehl

Funding

Hedgehog Signaling and Adult Liver RegenerationR01DK077794 · NIDDK · DUKE UNIVERSITY · PI DIEHL, ANNA MAE ELIZABETH · 2008 to 2020
$4.6M
NIAAA NIH HHS R01 AA01054NIDDK NIH HHS R01 DK077794
6 · The paper itself

Abstract

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive biology in hepatocellular carcinomas initiates a molecular cascade that results in EMT.

Indexed as

AnimalsCarcinoma, Hepatocellularcdc42 GTP-Binding ProteinCell DifferentiationDNA-Binding ProteinsDNA HelicasesEpithelial CellsHumansLiver CirrhosisLiver NeoplasmsMesodermMicecdc42 GTP-Binding ProteinCHD1L protein, humanDNA-Binding ProteinsDNA Helicases

Identifiers

PMID20335655
PMCPMC2846072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.